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Scientists develop mechanism to inactivate Covid by blocking entry to cells

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 Scientists have developed a design of a new class of synthetic peptides that can not only block the entry of SARS-CoV-2 virus entry into cells but also clump the virions (virus particles) together, reducing their ability to infect.

Scientists at the Indian Institute of Science (IISc), in collaboration with researchers from the CSIR-Institute of Microbial Technology, have made use of this approach to design peptides that can bind to and block the spike protein on the surface of SARS-CoV-2 virus, said the Ministry of Science and Technology on Wednesday.

This binding was further characterised extensively by cryo-electron microscopy (cryo-EM) and other biophysical methods. This novel approach provides an alternative mechanism to render viruses like SARS-CoV-2 inactive, promising a new class of peptides as antivirals.

The research was supported under the Covid-19 IRPHA call of SERB Science and Engineering Research Board (SERB), a statutory body of Department of Science and Technology (DST).

The designed peptides are helical, hairpin-shaped, each capable of pairing up with another of its kind, forming what is known as a dimer. Each dimeric ‘bundle’ presents two ‘faces’ to interact with two target molecules.

In the study published in Nature Chemical Biology, the researchers hypothesised that the two faces would bind to two separate target proteins locking all four in a complex and blocking the targets’ action. The team decided to test their hypothesis by using a peptide called SIH-5 to target the interaction between the Spike (S) protein of SARS-CoV-2 and ACE2 protein, the SARS-CoV-2 receptor in human cells.

The S protein is a trimer – a complex of three identical polypeptides. Each polypeptide contains a Receptor Binding Domain (RBD) that binds to the ACE2 receptor on the host cell surface. This interaction facilitates viral entry into the cell.

The SIH-5 peptide was designed to block the binding of the RBD to human ACE2. When a SIH-5 dimer encountered an S protein, one of its faces bound tightly to one of the three RBDs on the S protein trimer, and the other face bound to an RBD from a different S protein.

This ‘cross-linking’ allowed the SIH-5 to block both S proteins at the same time. Under cryo-EM, the S proteins targeted by SIH-5 appeared to be attached head-to-head, and the spike proteins were being forced to form dimers.

Subsequently, the researchers showed that SIH-5 inactivated the viruses efficiently by cross-linking the spike proteins from different virus particles.

The team consisting of B Khatri, I Pramanick, SK Malladi, RS Rajmani, P Ghosh, N Sengupta, R Varadarajan, S Dutta and J Chatterjee from Indian Institute of Science (IISc), R Rahisuddin, S Kumar, N Kumar, S Kumaran and RP Ringe from CSIR-Institute of Microbial Technology, tested the peptide for toxicity in mammalian cells in the lab and found it to be safe.

When hamsters were dosed with the peptide and subsequently exposed to a high dose of SARS-CoV-2, they showed decreased viral load as well as much less cell damage in the lungs compared to hamsters exposed only to the virus, demonstrating the promise of this class of peptides as antivirals.

The researchers believe that with minor modifications and peptide engineering, this lab-made miniprotein could inhibit other protein-protein interactions as well.

Maharashtra

Mumbai Municipal Corporation Elections 2025-26: Final voter lists with voter photographs available for sale at the Central Election Office

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Mumbai: State Election Commission, Maharashtra has announced a revised schedule for publication of polling station wise voter lists in connection with the Municipal Corporation General Elections 2025-26. The order states that the complete municipality wise voter list shall be published as soon as it is completed. Accordingly, Mumbai Municipal Corporation has received polling station wise voter lists of 226 out of 227 wards from the State Election Commission today, January 6, 2026. The said lists along with polling station wise voter photographs are available for sale at the concerned Central Election Offices from Wednesday, January 7, 2026. The Municipal Administration appeals to the citizens/political parties to purchase these voter lists from the concerned Central Election Offices.

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If Uddhav Thackeray is elected unopposed then everything is fine, if someone else is elected then it is wrong: Deepak Kesarkar

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Mumbai: During the municipal elections, the leaders of the Uddhav Thackeray group are constantly trying to spread chaos. Sometimes they are spreading wrong information and sometimes they are doing politics in the name of Chhatrapati Shivaji Maharaj. Former Shiv Sena minister and MLA Deepak Kesarkar expressed his strong displeasure and reacted strongly to this irresponsible statement of the UBT. In a press conference held in Mumbai, Deepak Kesarkar said that the UBT leaders are busy defaming Maharashtra. They do not have any development plan, hence they are constantly making misleading and unnecessary statements. Shiv Sena national spokesperson Shaina NC was also present at the press conference.

Deepak Kesarkar questioned the UBT leaders and said that if Uddhav Thackeray can be elected unopposed, why not other candidates? It is wrong to repeatedly question the election process. The Election Commission works with complete transparency and under this transparency, all the candidates were elected unopposed. UBT has no development agenda, while Mahayoti is moving forward with development issues, which is why people have faith in Mahayoti.

Reacting strongly to Sanjay Raut’s statements, Deepak Kesarkar said that Chhatrapati Shivaji Maharaj belongs not only to Maharashtra but to the entire country. The kind of politics Sanjay Raut is playing in the name of a great personality shows that his health is still not good. He should re-evaluate himself so that he can stop making such absurd statements.

He added that Chhatrapati Shivaji Maharaj was given the highest honour during the tenure of Prime Minister Narendra Modi. Shivaji Maharaj’s emblem was included in the Indian Navy’s emblem, a move that no government had done before.

Shiv Sena national spokesperson Shaina NC targeted UBT and said that in the last 25 years, Mumbai has been full of potholes. However, now Shiv Sena central leader and Deputy Chief Minister Eknath Shinde has pledged to make Mumbai pothole-free. The work has started, and by 2027, all the roads of Mumbai will be pothole-free.

He added that a detailed blueprint for Mumbai was prepared in an important meeting between Deputy Chief Minister Eknath Shinde and Transport Minister Pratap Sarnaik. Under this blueprint, several important decisions related to roads and transportation have been taken, which will provide significant relief to the people of Mumbai.

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Maharashtra

Mumbai municipal elections: A series of rebellions among political parties

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Mumbai: Ahead of the Mumbai municipal elections, the migration of disgruntled party leaders to other parties has begun. Maharashtra Navnirman Sena has suffered a major setback before the municipal elections. Several MNS leaders have joined Shiv Sena Shinde Sena. Along with this, Santosh Dhuri, a close associate of Raj Thackeray, joined the BJP. Even after this, the party change is not stopping and many senior MNS leaders have joined Shiv Sena Eknath Shinde and raised the flag of rebellion against the party. Before the BMC elections in Mumbai, Raj and Uddhav Thackeray had formed an electoral alliance, but the rebel leaders of these parties are still separating from the party, due to which there is a long series of rebellions in both the parties. Many leaders, unhappy with not getting tickets, are leaving their party and joining other parties. Maharashtra Navnirman Sena General Secretary Raja Bhau Chogle, MNS spokesperson Hemant Kamble, MNS Chhatrapati Sena General Secretary Rahul Topalonde, Maharashtra Navnirman Vidyarthi Sena Sandesh Shetty, Munawar Sheikh, Ashish Mark, Prathamesh Banerjee, Santosh Yadav joined Shiv Sena in the presence of Deputy Chief Minister Eknath Shinde. On this occasion, Shinde welcomed all of them into the party and wished them well for their future. On this occasion, Shiv Sena General Secretary Rahul Shivale, Shiv Sena Secretary Sushant Shelar, Shiv Sena spokesperson Sheetal Mahatre and all local office bearers and workers of Shiv Sena were present.

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