General
Scientists develop mechanism to inactivate Covid by blocking entry to cells
Scientists have developed a design of a new class of synthetic peptides that can not only block the entry of SARS-CoV-2 virus entry into cells but also clump the virions (virus particles) together, reducing their ability to infect.
Scientists at the Indian Institute of Science (IISc), in collaboration with researchers from the CSIR-Institute of Microbial Technology, have made use of this approach to design peptides that can bind to and block the spike protein on the surface of SARS-CoV-2 virus, said the Ministry of Science and Technology on Wednesday.
This binding was further characterised extensively by cryo-electron microscopy (cryo-EM) and other biophysical methods. This novel approach provides an alternative mechanism to render viruses like SARS-CoV-2 inactive, promising a new class of peptides as antivirals.
The research was supported under the Covid-19 IRPHA call of SERB Science and Engineering Research Board (SERB), a statutory body of Department of Science and Technology (DST).
The designed peptides are helical, hairpin-shaped, each capable of pairing up with another of its kind, forming what is known as a dimer. Each dimeric ‘bundle’ presents two ‘faces’ to interact with two target molecules.
In the study published in Nature Chemical Biology, the researchers hypothesised that the two faces would bind to two separate target proteins locking all four in a complex and blocking the targets’ action. The team decided to test their hypothesis by using a peptide called SIH-5 to target the interaction between the Spike (S) protein of SARS-CoV-2 and ACE2 protein, the SARS-CoV-2 receptor in human cells.
The S protein is a trimer – a complex of three identical polypeptides. Each polypeptide contains a Receptor Binding Domain (RBD) that binds to the ACE2 receptor on the host cell surface. This interaction facilitates viral entry into the cell.
The SIH-5 peptide was designed to block the binding of the RBD to human ACE2. When a SIH-5 dimer encountered an S protein, one of its faces bound tightly to one of the three RBDs on the S protein trimer, and the other face bound to an RBD from a different S protein.
This ‘cross-linking’ allowed the SIH-5 to block both S proteins at the same time. Under cryo-EM, the S proteins targeted by SIH-5 appeared to be attached head-to-head, and the spike proteins were being forced to form dimers.
Subsequently, the researchers showed that SIH-5 inactivated the viruses efficiently by cross-linking the spike proteins from different virus particles.
The team consisting of B Khatri, I Pramanick, SK Malladi, RS Rajmani, P Ghosh, N Sengupta, R Varadarajan, S Dutta and J Chatterjee from Indian Institute of Science (IISc), R Rahisuddin, S Kumar, N Kumar, S Kumaran and RP Ringe from CSIR-Institute of Microbial Technology, tested the peptide for toxicity in mammalian cells in the lab and found it to be safe.
When hamsters were dosed with the peptide and subsequently exposed to a high dose of SARS-CoV-2, they showed decreased viral load as well as much less cell damage in the lungs compared to hamsters exposed only to the virus, demonstrating the promise of this class of peptides as antivirals.
The researchers believe that with minor modifications and peptide engineering, this lab-made miniprotein could inhibit other protein-protein interactions as well.
Maharashtra
NCB seizes city drugs, sets them on fire

Mumbai: The Mumbai Zonal Unit of the Mumbai Narcotics Control Bureau (NCB) has disposed of about 1835 kg of Mephedrone along with 341 kg of other substances which were seized from various places in Maharashtra and Delhi. 16 persons were arrested in this case. A thorough investigation into the massive drug seizure led to the arrest of several persons including foreigners from various places, resulting in the elimination of close associates of the drug peddlers with international links.
As per the guidelines prescribed by the Hon’ble Supreme Court, a high-level Drug Disposal Committee was constituted comprising Deputy Director General (SWR) of NCB, Additional Director, NCB Mumbai Zonal Unit and Additional Commissioner of Pune Police. The case was reviewed and it was selected to dispose of the drug hoard. Accordingly, all legal conditions were complied with after which the seized drugs along with other chemicals were finally destroyed by incineration in the presence of HLDCC on 14th November 2025 at Maple, Ranjangaon, Pune, Maharashtra.
This significant seizure of drugs followed by disposal of the sub-judices, indicates the continuous efforts of NCB in dismantling organised drug syndicates and targeting drug offenders who pollute the drug ecosystem. The Bureau is steadfast in its mission to protect public health and uphold the vision of “Nisha Mukt Bharat” by 2047.
NCB is firmly committed to ensuring a drug-free society under the guidance of which it has curbed drug trafficking, broken financial nexus and curbed inter-state and international drug syndicates.
Citizens are urged to play their role by reporting any information related to drugs through the MANS – National Narcotics Helpline (Toll Free Number: 1933). The identity of the informants is kept strictly confidential.
Maharashtra
Three men accused of robbing a youth have been arrested The main accused was apprehended in Titwala.

Mumbai: A young man returning home on a motorcycle in the Asalpha area of Ghatkopar was attacked and forcibly robbed by three men who brandished a chopper. A case was registered at the Ghatkopar police station under sections 309(4), 3(5) of the Indian Penal Code, sections 4, 25 of the Indian Penal Code, and sections 37(1) and 135 of the Indian Penal Code.
The complainant, Suraj Mahadev Dethe (24), and his friend, Yash Kamble, were passing near the Home Guard Training Center at approximately 1:30 a.m. on November 12th when three unidentified individuals in a three-wheeled tempo stopped them. The accused, using the chopper as a pointer, assaulted them, abused them, and stole their Honda Dio scooter and mobile phone.
As soon as the case was registered, the Assistant Commissioner of Police and Senior Police Inspector of the Ghatkopar Division inspected the scene. Based on technical and traditional investigations, the accused identified Hussain Aslam Memon, alias Genda. Upon receiving information that he was hiding in the Titwala area, the police apprehended him. During interrogation, he revealed the names of his accomplices – Munna Ramvilas Sharma and Dilshaduddin Sitabuddin Shaikh – who were subsequently arrested.
On November 13, the three accused were produced in court, where they were remanded to police custody until November 17. The investigation also revealed that Genda is a notorious criminal with more than 13 cases registered against him in various police stations.
Maharashtra
4-year-old girl kidnapped from Mumbai recovered from Varanasi after 6 months, Mumbai Police finds clues

Mumbai: Mumbai Police has succeeded in locating a 4-year-old girl after the Mumbai-Sholapur-CST train arrived in Mumbai. According to the details, the girl had come to Mumbai with her parents on May 20, 2025. During this time, an unknown person kidnapped the girl and took her from Mumbai to UP. After that, the police formed several teams to search for the girl and then one team was sent to Banaras. Here, the police took the help of social media and the media and made the girl’s picture viral. After that, a journalist told the police that there was a Marathi-speaking child in an orphanage here. After that, the police reached the place and confirmed it and brought the girl to Mumbai with documents on November 12. This operation was carried out by DCP Praveen Munde and the staff of M.A. Marg and Azad Maidan police on the instructions of Mumbai Police Commissioner Deven Bharti.
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