General
Scientists develop mechanism to inactivate Covid by blocking entry to cells
Scientists have developed a design of a new class of synthetic peptides that can not only block the entry of SARS-CoV-2 virus entry into cells but also clump the virions (virus particles) together, reducing their ability to infect.
Scientists at the Indian Institute of Science (IISc), in collaboration with researchers from the CSIR-Institute of Microbial Technology, have made use of this approach to design peptides that can bind to and block the spike protein on the surface of SARS-CoV-2 virus, said the Ministry of Science and Technology on Wednesday.
This binding was further characterised extensively by cryo-electron microscopy (cryo-EM) and other biophysical methods. This novel approach provides an alternative mechanism to render viruses like SARS-CoV-2 inactive, promising a new class of peptides as antivirals.
The research was supported under the Covid-19 IRPHA call of SERB Science and Engineering Research Board (SERB), a statutory body of Department of Science and Technology (DST).
The designed peptides are helical, hairpin-shaped, each capable of pairing up with another of its kind, forming what is known as a dimer. Each dimeric ‘bundle’ presents two ‘faces’ to interact with two target molecules.
In the study published in Nature Chemical Biology, the researchers hypothesised that the two faces would bind to two separate target proteins locking all four in a complex and blocking the targets’ action. The team decided to test their hypothesis by using a peptide called SIH-5 to target the interaction between the Spike (S) protein of SARS-CoV-2 and ACE2 protein, the SARS-CoV-2 receptor in human cells.
The S protein is a trimer – a complex of three identical polypeptides. Each polypeptide contains a Receptor Binding Domain (RBD) that binds to the ACE2 receptor on the host cell surface. This interaction facilitates viral entry into the cell.
The SIH-5 peptide was designed to block the binding of the RBD to human ACE2. When a SIH-5 dimer encountered an S protein, one of its faces bound tightly to one of the three RBDs on the S protein trimer, and the other face bound to an RBD from a different S protein.
This ‘cross-linking’ allowed the SIH-5 to block both S proteins at the same time. Under cryo-EM, the S proteins targeted by SIH-5 appeared to be attached head-to-head, and the spike proteins were being forced to form dimers.
Subsequently, the researchers showed that SIH-5 inactivated the viruses efficiently by cross-linking the spike proteins from different virus particles.
The team consisting of B Khatri, I Pramanick, SK Malladi, RS Rajmani, P Ghosh, N Sengupta, R Varadarajan, S Dutta and J Chatterjee from Indian Institute of Science (IISc), R Rahisuddin, S Kumar, N Kumar, S Kumaran and RP Ringe from CSIR-Institute of Microbial Technology, tested the peptide for toxicity in mammalian cells in the lab and found it to be safe.
When hamsters were dosed with the peptide and subsequently exposed to a high dose of SARS-CoV-2, they showed decreased viral load as well as much less cell damage in the lungs compared to hamsters exposed only to the virus, demonstrating the promise of this class of peptides as antivirals.
The researchers believe that with minor modifications and peptide engineering, this lab-made miniprotein could inhibit other protein-protein interactions as well.
Maharashtra
Mumbai Police Suspend Licences of 11 Dance Bars for One Month

Mumbai, July 4: ( By Kamar Ansari ) In a major enforcement action, the Mumbai Police have suspended the licences of 11 dance bars across the city for a period of one month.
According to official information, the action was taken by the Licensing Department of the Mumbai Police following alleged violations of licence conditions and applicable regulations. During the suspension period, the establishments will not be permitted to operate.
The dance bars whose licences have been suspended are: Urvashi, Commando, Chiranjeevi, Senorita, Sapphire, Sunshine Punjab, Raj Palace, Blue Diamond, Sai Prasad, Swagatam, and Vikas Kuch Home.
Mumbai Police stated that the action forms part of ongoing efforts to ensure compliance with licensing rules and maintain regulatory standards. Authorities have also indicated that inspections and enforcement drives will continue, and strict action may be taken against establishments found violating licence conditions.
Further details regarding the specific violations in each case are expected to be released by the authorities.
Maharashtra
Mumbai: Red alert issued for extremely heavy rainfall on Sunday; citizens advised to avoid stepping out unless necessary.

Mumbai: In view of the ongoing heavy rains in Mumbai, the entire Mumbai Municipal Corporation system is working on a war footing. More than 10,000 officers and employees of the Municipal Corporation are deployed in various parts and are continuously monitoring the situation and taking necessary measures. Due to the continuous heavy rains, water has accumulated in some low-lying areas and traffic has been temporarily closed on some roads in view of the safety of the citizens. The India Meteorological Department has issued a red alert for heavy rains on Sunday, July 5, 2026 and the Burhan Mumbai Municipal Corporation administration is appealing to the citizens not to step out of their homes unnecessarily.
In view of the ongoing heavy rains in Mumbai, State Disaster Management Minister Girish Mahajan today visited the Emergency Control Room at the Municipal Corporation headquarters. He also reviewed the situation in Mumbai. Also, Mumbai Mayor Ritu Tawde visited the Emergency Control Room at the Mumbai Municipal Corporation Headquarters today (July 4, 2026) and reviewed the entire situation.
Meanwhile, Municipal Commissioner Ashwini Bhide is continuously reviewing the situation from the Emergency Control Room at the Mumbai Municipal Corporation Headquarters. Additional Municipal Commissioner (Projects) Abhijeet Bangar, Additional Municipal Commissioner (Eastern Suburbs) Avinash Dhakne, Deputy Commissioner (Public Health) Sharad Uday, Director (Emergency Management) Mahesh Narvekar, Principal Officer (Emergency Management) Rashmi Lokhande and concerned officers are present.
Mumbai city and suburbs have been receiving heavy rain since the morning of July 4, 2026. As a precautionary measure for the safety of students, a holiday has been declared for the afternoon session in all private/government schools and colleges in Mumbai on July 4, 2026.
Due to heavy rains in the western suburbs, the Mogra Nallah is overflowing and the smaller drains connected to the Mogra Nallah system are also overflowing. Due to which some roads in the area are submerged in water and traffic is affected. The continuous rain is delaying the drainage of water. In this backdrop, Noor Elahi Seva Road in Chembur, Veera Desai Road in Andheri, Municipal Market Road, Swami Vivekananda Marg, Andheri Bhuvari Marg, Himamaal Junction in Vikhroli, Gandhi Nagar Junction and Parish Park Market roads were temporarily closed for traffic as a precautionary measure. An appeal was made to take alternative routes.
All Zonal Deputy Commissioners and all Assistant Commissioners (Ward Officers) along with concerned officers and employees are present in the office or in their actual work areas. The Deputy Commissioners should personally verify this, Municipal Commissioner Ashwini Bhide has given clear instructions. As per these instructions, the entire Mumbai Municipal Corporation system is on alert, and officers and employees are working in their actual work areas to deal with any emergency. Heads of all departments, engineers, pump operators, health workers and emergency response teams have been deployed at various locations. Currently, 10,000 employees are working in the field, constantly monitoring the situation and taking necessary measures. Complaints received from citizens through the Municipal Corporation’s emergency control room are being recorded immediately and forwarded to the concerned departments for immediate action. Special attention has been paid to the performance of storm water systems, sewage systems and pumping stations and necessary measures are being taken on a war footing to ensure smooth drainage of rainwater. Officers and employees of the Solid Waste Management Department are working in the field, and health workers are providing continuous services at various locations to ensure that floating solid waste, tree branches and other waste flowing with rainwater do not get stuck in manholes or drains and obstruct the flow of water. The Mumbai Municipal Corporation is working round the clock to ensure that even during heavy rains, the area remains clean, there is no foul smell and Mumbaikars do not face any inconvenience, and all the concerned employees are taking necessary measures together.
In the backdrop of the ongoing monsoon situation, the Municipal Corporation administration has appealed to the citizens to take necessary precautions to avoid the disease of Leptospirosis. The field employees of the Municipal Corporation should also take Doxycycline 200 mg as a preventive medicine for Leptospirosis. These tablets are available from the Municipal Corporation dispensary/dispensary.
Maharashtra
Mumbai bank accounts activated, cyber fraud company exposed, 6 arrested

Mumbai: Crime Branch has claimed to have busted a gang that was providing bank accounts for cyber fraud. In this case, the police have arrested 6 accused. The Mumbai Crime Branch received information that bank accounts were being provided for cyber fraud through a fake company at Masjid Bandar and bank accounts were activated and money was deposited in the account under the knowledge of the same company. On this basis, the Crime Branch conducted a raid and exposed this racket. Accounts were opened in several banks in Mumbai and details of new current accounts were obtained. After activating the bank account with the SIM card, the above SIM card was sent to Dubai and from here this SIM card was used for cyber fraud. On this basis, Unit 2 Crime Branch raided and seized a total of 66 ATM cards of several banks, 12 mobile SIM cards, 15 passbooks of several banks, 122 cheque books of several banks, 2 pen drives, 68 stamps, bank account opening forms, electricity bills and other documents. The accused have been produced in court and sent to remand. This information was given here today by Mumbai Crime DCP Raj Tilak Roshan.
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