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Mumbai startup develops India’s first universal gene test for infectious disease

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Mumbai-based health-tech startup HaystackAnalytics has developed the first of its kind universal infectious diseases (ID) gene test to identify existing and emerging infections, the company said on Monday.

The company is supported by the Department of Science and Technology, as well as several private healthcare players.

To identify infections, the company deploys Next-Generation Sequencing (NGS) technology and Artificial Intelligence (AI), and also provides information on drug resistance to support and identify correct treatment options for patients.

The new Universal Infectious Diseases test will be rolled out with their current partners in a phased manner over the next three months, the company said in a statement.

It will initially be targeted at identifying and treating sepsis in Intensive Care Unit (ICU) patients, but gradually be made available to anyone suffering from a fever of unknown origin, by eradicating the need to conduct multiple tests.

The test comes at an opportune time, as Covid-19 pandemic highlights the need for better diagnostic technologies, appropriate antibiotic use, and the renewed importance of infection prevention strategies.

“The test enables rapid (within hours) and comprehensive (covering nearly all known bacterial and fungal pathogens) screening in a near to point of care deployment. Leveraging the power of next generation sequencing and AI, the team of scientists and engineers at Haystack has been able to eliminate the need for a redundant and expensive battery of tests, with a single test,” Dr. Anirvan Chatterjee, Co Founder and CEO of HaystackAnalytics, said.

“Our single point focus is to prevent each and every death caused due to treatable infections. Genomics has the potential to reduce trial and error in disease management and bring equality of access to high quality healthcare,” he added.

In the past, HaystackAnalytics had partnered with various diagnostic centers and over 20 hospitals including AIIMS, to introduce their sequencing-based clinical products for Tuberculosis and Covid in the past.

It is while working on two of the most debilitating infectious diseases — Tuberculosis and Covid — the company said it recognised the true burden of inaccurate diagnosis of infections in India and the world.

While the novel coronavirus infected and killed millions of people across the globe, there are various other infectious diseases that continue to plague India.

In particular, India accounts for the largest number of sepsis cases (11.3 million) and sepsis-related deaths (2.9 million) in the world, as per a global study published in the Lancet in 2020.

Despite having a wide range of antibiotics and antifungal medicines, sepsis is a life-threatening organ failure. It occurs when the body ends up injuring its own tissues and organs, in response to an infection, leading to shock, disability, multi-organ failure, and even death if left untreated in the early stages.

“A large proportion of these deaths can be avoided by early and accurate identification of the pathogen causing the infection. Haystack’s UID test has been developed to solve this exact problem,” Chatterjee said.

Business

Top 10 firms add nearly Rs 93,000 crore in market value last week

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Mumbai, July 12: The combined market valuation of four of India’s 10 most-valued companies increased by Rs 92,995.48 crore during the last week, with HDFC Bank and Bharti Airtel emerging as the biggest gainers, even as the broader equity market ended lower.

During the week, the Sensex declined 194.52 points, or 0.25 per cent, while the Nifty slipped 63.95 points, or 0.26 per cent.

Among the country’s 10 most-valued companies, Reliance Industries, HDFC Bank, Bharti Airtel, and Life Insurance Corporation of India (LIC) registered gains in their market capitalisation.

In contrast, ICICI Bank, State Bank of India (SBI), Tata Consultancy Services (TCS), Bajaj Finance, Larsen & Toubro (L&T), and Hindustan Unilever together witnessed an erosion of Rs 49,294.13 crore in their market valuation.

HDFC Bank recorded the largest increase in market capitalisation during the week, with its valuation rising by Rs 35,808.09 crore to Rs 12,69,454.42 crore.

Bharti Airtel followed closely, adding Rs 34,896.92 crore to take its market valuation to Rs 11,98,774.22 crore.

LIC’s market capitalisation rose by Rs 16,065.5 crore to Rs 5,60,205.05 crore, while Reliance Industries added Rs 6,224.97 crore, taking its valuation to Rs 17,71,206.33 crore.

On the losing side, Hindustan Unilever registered the steepest decline, with its market capitalisation falling by Rs 12,088.65 crore to Rs 5,04,997.65 crore.

Larsen & Toubro’s valuation declined by Rs 11,040.23 crore to Rs 5,42,938.40 crore, while TCS lost Rs 8,574.87 crore in market value, ending the week at Rs 7,48,600.40 crore.

Bajaj Finance saw its market capitalisation shrink by Rs 7,813.58 crore to Rs 6,35,327.78 crore. ICICI Bank’s valuation slipped by Rs 6,315.32 crore to Rs 10,05,379.71 crore, while SBI’s market value declined by Rs 3,461.48 crore to Rs 9,56,430.44 crore.

Despite the mixed performance, Reliance Industries retained its position as India’s most-valued company by market capitalisation. It was followed by HDFC Bank, Bharti Airtel, ICICI Bank, State Bank of India, TCS, Bajaj Finance, LIC, Larsen & Toubro and Hindustan Unilever.

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Maharashtra

Pune building collapse: Death toll climbs to 8, one person still missing

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Pune, July 12: The death toll in the Moshi garbage dump collapse in Pune’s Pimpri-Chinchwad has increased to eight after rescue teams recovered the bodies of seven more victims from the damaged administrative building of the Waste-to-Energy project on Saturday, officials said on Sunday.

Rescue personnel also confirmed that one person is still unaccounted for, and search operations are continuing to locate the missing individual.

The incident occurred at around 1:30 p.m. on Wednesday when a massive mound of garbage gave way and crashed onto the administrative building located inside the Moshi garbage depot operated by the Pimpri-Chinchwad Municipal Corporation.

At the time of the collapse, a total of 23 people were trapped. Of them, 22 were inside the administrative building, while one person was buried beneath a large heap of garbage adjacent to the structure.

Five individuals managed to escape safely immediately after the incident.

Following the collapse, authorities launched an extensive rescue operation involving personnel from the Indian Army, the National Disaster Response Force (NDRF), the Pimpri-Chinchwad Municipal Corporation, the Pune Metropolitan Region Development Authority (PMRDA) Fire Services and the police.

On the first day of the operation, rescue teams succeeded in pulling nine people out of the damaged building alive. Search efforts then continued to locate those who remained trapped inside the debris.

On Thursday, rescuers recovered Bhavesh Wani from the collapsed structure and immediately shifted him to a hospital. However, doctors declared him dead upon arrival.

The operation to reach the remaining victims continued over the following days, but rescue teams encountered major challenges due to the unstable condition of the damaged building, which posed a significant risk to personnel involved in the mission.

To facilitate the rescue work, heavy machinery, including 12 excavators, dumpers and JCB machines, was deployed to remove debris surrounding the building and create a safer passage for rescue teams.

Despite continuous efforts, the precarious state of the structure made it extremely difficult for rescuers to enter the building.

In a bid to accelerate the operation, two advanced demolition excavators were brought to the site on Friday night.

Working under the technical supervision of the NDRF, rescue personnel carefully dismantled the most hazardous concrete sections of the collapsed building in a controlled manner.

The process enabled teams to gain access to the interior of the structure and resume the search operation.

During the rescue operation on Saturday, teams located seven people trapped inside the building. All seven were immediately shifted to a hospital in Pimpri, where medical officers examined them and declared them dead.

With the recovery of these bodies, the overall death toll in the tragedy has risen to eight.

Meanwhile, one individual, believed to be buried beneath the garbage mound adjacent to the collapsed building, remains missing. Rescue personnel continue to carry out the search operation on a war footing.

Officials said NDRF dog squads, along with specialised search equipment, are being used to locate the missing person.

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Maharashtra

Bomb threat at Mumbai’s Taj Hotel declared hoax after security check

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Mumbai, July 12: A bomb threat targeting the iconic Taj Hotel in Mumbai triggered a security alarm, prompting police and security agencies to conduct a comprehensive search operation at the premises before declaring that the threat was a hoax, said police on Sunday.

According to officials, the Taj Hotel was placed on high alert after, at around 12:13 a.m., a man called the Navi Mumbai Police Control Room and allegedly claimed, “Dawood has planted a bomb at the Taj Hotel”. The information was immediately relayed to the Mumbai Police Main Control Room.

Following the alert, teams from the Colaba Police, the Crime Branch, and the Bomb Detection and Disposal Squad (BDDS) rushed to the Taj Hotel and launched an extensive security check. The hotel’s main lobby, swimming pool, banquet halls, restaurants, parking area, outer premises, and other sensitive locations were thoroughly searched.

After an exhaustive inspection, police confirmed that no suspicious object or explosive was found on the premises. The bomb threat was found to be a hoax.

Technical investigation revealed that the threatening call originated from the Turbhe area of Navi Mumbai. Police have launched a search to identify and arrest the caller based on the mobile number used. Authorities are working with the Turbhe Police to trace and apprehend the suspect.

The iconic hotel in the city’s Colaba area was one of the primary targets in the 26/11 Mumbai terror attack, in which 166 people were killed and hundreds injured.

A similar bomb threat was received by the Mumbai Police during which the caller allegedly claimed that Delhi’s historic Red Fort would be blown up, prompting police and security agencies to conduct a comprehensive search of the monument on Saturday. It was later declared to be a hoax.

According to Delhi Police, the threat originated from a phone call to the Mumbai Police Control Room, which immediately relayed the information to their Delhi counterpart, which, in turn, alerted the North District Police to initiate security measures.

Soon after receiving the alert, police personnel, bomb disposal squads, and other security teams rushed to the Red Fort and carried out an extensive sanitisation and inspection of the premises. After thoroughly checking the area, officials found no suspicious object or explosive material and confirmed that the threat was false.

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