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Mumbai startup develops India’s first universal gene test for infectious disease

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Mumbai-based health-tech startup HaystackAnalytics has developed the first of its kind universal infectious diseases (ID) gene test to identify existing and emerging infections, the company said on Monday.

The company is supported by the Department of Science and Technology, as well as several private healthcare players.

To identify infections, the company deploys Next-Generation Sequencing (NGS) technology and Artificial Intelligence (AI), and also provides information on drug resistance to support and identify correct treatment options for patients.

The new Universal Infectious Diseases test will be rolled out with their current partners in a phased manner over the next three months, the company said in a statement.

It will initially be targeted at identifying and treating sepsis in Intensive Care Unit (ICU) patients, but gradually be made available to anyone suffering from a fever of unknown origin, by eradicating the need to conduct multiple tests.

The test comes at an opportune time, as Covid-19 pandemic highlights the need for better diagnostic technologies, appropriate antibiotic use, and the renewed importance of infection prevention strategies.

“The test enables rapid (within hours) and comprehensive (covering nearly all known bacterial and fungal pathogens) screening in a near to point of care deployment. Leveraging the power of next generation sequencing and AI, the team of scientists and engineers at Haystack has been able to eliminate the need for a redundant and expensive battery of tests, with a single test,” Dr. Anirvan Chatterjee, Co Founder and CEO of HaystackAnalytics, said.

“Our single point focus is to prevent each and every death caused due to treatable infections. Genomics has the potential to reduce trial and error in disease management and bring equality of access to high quality healthcare,” he added.

In the past, HaystackAnalytics had partnered with various diagnostic centers and over 20 hospitals including AIIMS, to introduce their sequencing-based clinical products for Tuberculosis and Covid in the past.

It is while working on two of the most debilitating infectious diseases — Tuberculosis and Covid — the company said it recognised the true burden of inaccurate diagnosis of infections in India and the world.

While the novel coronavirus infected and killed millions of people across the globe, there are various other infectious diseases that continue to plague India.

In particular, India accounts for the largest number of sepsis cases (11.3 million) and sepsis-related deaths (2.9 million) in the world, as per a global study published in the Lancet in 2020.

Despite having a wide range of antibiotics and antifungal medicines, sepsis is a life-threatening organ failure. It occurs when the body ends up injuring its own tissues and organs, in response to an infection, leading to shock, disability, multi-organ failure, and even death if left untreated in the early stages.

“A large proportion of these deaths can be avoided by early and accurate identification of the pathogen causing the infection. Haystack’s UID test has been developed to solve this exact problem,” Chatterjee said.

Maharashtra

Maharashtra Assembly Elections 2024: Central Railway To Run Special Suburban Trains From November 19-21 For Voters & Election Personnel

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In view of the Maharashtra Assembly Elections, Central Railway will run special suburban trains on November 19-20, 2024 (Tuesday-Wednesday night) and November 20-21, 2024 (Wednesday-Thursday night) to facilitate the movement of election personnel and the public.

These trains will operate on the Main Line (CSMT-Kalyan) and Harbour Line (CSMT-Panvel), with specific departure and arrival times as listed below.

Schedule for Special Suburban Trains:

1. Tuesday-Wednesday Night (November 19-20, 2024)

Main Line (Down): CSMT – Kalyan Special: Departs CSMT at 03:00 hrs, arrives at Kalyan at 04:30 hrs.

Main Line (UP): Kalyan – CSMT Special: Departs Kalyan at 03:00 hrs, arrives at CSMT at 04:30 hrs.

Harbour Line (Down): CSMT- Panvel Special: Departs CSMT at 03:00 hrs, arrives at Panvel at 04:20 hrs.

Harbour Line (Up): Panvel – CSMT Special 2: Departs Panvel at 03:00 hrs, arrives CSMT at 04:20 hrs.

2. Wednesday-Thursday Night (November 20-21, 2024)

Main Line (Down): CSMT – Kalyan Special: Departs CSMT at 01:10 hrs, arrives at Kalyan at 02:40 hrs.

CSMT – Kalyan Special: Departs CSMT at 02:30 hrs, arrives at Kalyan at 04:00 hrs.

Main Line (Up): Kalyan – CSMT Special: Departs Kalyan at 01:00 hrs, arrives CSMT at 02:30 hrs.

Kalyan – CSMT Special: Departs Kalyan at 02:00 hrs, and arrives at CSMT at 03:30 hrs.

Harbour Line (Down): CSMT- Panvel Special: Departs CSMT at 01:40 hrs, arrives at Panvel at 03:00 hrs.

CSMT- Panvel Special: Departs CSMT at 02:50 hrs, arrives at Panvel at 04:10 hrs.

Harbour Line (Up): CSMT- Panvel Special: Departs Panvel at 01:00 hrs, arrives CSMT at 02:20 hrs.

CSMT- Panvel Special: Departs Panvel at 02:30 hrs, arrives CSMT at 03:50 hrs.

All special trains will halt at all stations between CSMT-Kalyan and CSMT-Panvel, as per the schedules listed above.

These special services are expected to enhance connectivity and ensure the smooth transit of election participants. Passengers are encouraged to take advantage of these additional services for their travel needs on these nights. We hope this initiative will empower voters to exercise their right to vote.

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Maharashtra

Maharashtra Assembly Elections 2024: BMC Launches Initiatives To Boost Voter Turnout Ahead Of November 20 Polls

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Mumbai: Given the lower voter turnout in Mumbai in the previous elections, the BMC has undertaken several initiatives to boost voter participation in the November 20 state polls.

Some of the key efforts include the rationalisation of polling stations (ensuring that they are at convenient distance), establishment of voting facilities within housing societies and making essential facilities available at polling stations.

BMC Chief Bhushan Gagrani Reviews Election Arrangements

BMC chief Bhushan Gagrani, who is also the district election officer, reviewed the election arrangements on Friday. Steps have been taken to address past issues like distant polling stations and long queues. As a result, polling stations have been rationalised for better convenience. Their number has increased from 2,509 in the previous Lok Sabha elections to 2,538 in Mumbai.

Similarly, now there are 7,574 voting booths in the suburbs as compared to 7,384 in general polls. Other initiatives include ‘Know Your Polling Station’ campaign, transportation facility for Person with Disability voters.

“Awareness campaigns are being amplified through media, street plays, celebrity outreach and activities like rap songs and flash mobs,” said a civic official. Polling stations have been rationalised to accommodate 1,200 to 1,300 voters each, with increased stations in high-rise buildings.

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Maharashtra

Maharashtra Assembly Elections 2024: Congress Files Complaint Against PM Modi & Union Home Minister Amit Shah For Alleged Slander & Divisive Remarks

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The Congress has filed a complaint against Prime Minister Narendra Modi and Home Minister Amit Shah with the Election Commission of India (ECI) for their alleged “false, divisive, malicious and slanderous statements which breach norms of electoral conduct and extant law”.

About The Case Of PM Modi

In the case of Modi, it charged that during an election rally at Nashik and Dhule on November 8 he made a series of false, malicious, and slanderous statements targeting the Congress and its allies. The complaints with respect to Modi, filed by Congress general secretary Jairam Ramesh, said Modi claimed that the current leadership of the Congress was “opposed to the interests of the ST, SC and OBC communities” and was “actively promoting infighting” among these communities. In this regard, the Congress cited a transcribed version of Modi’s statement, in which he said, “On the one hand, Congress and its allies in J&K want to snatch rights of Dalits, Tribals and OBCs by demanding restoration of Article 370. On the other hand, they wave a blank red book in the name of the Constitution to hoodwink Dalits, Tribals and OBCs in Maharashtra.”

The Congress also quoted Modi as saying that “the three former Congress PMs – Jawaharlal Nehru, Indira Gandhi & Rajiv Gandhi were opposed to giving reservations to Dalits, Tribals and OBCs. The Congress claimed that “the tone and tenor of the entire speech is further evidence of the speaker’s (Modi’s) intention to create and spread religious and caste-based animosity.”

Similarly, during an election rally in Chandrapur on November 12, the Congress accused Modi of repeating his “false and unfounded allegations”. Here it quoted Modi as saying, “If the Adivasi community gets divided into castes, it will end its identity and strength. The prince of Congress (Rahul Gandhi) has announced this in a foreign country.”

About The Case Of Home Minister Amit Shah

Similarly, in the case of Amit Shah, the Congress accused him of levelling false allegations against the party and its leaders during his election rally in Dhanbad on November 12. Stating that these actions constitute a violation of the Model Code of Conduct and the Representation of the People Act, 1951, and also constitute offences punishable under the provisions of the Bharatiya Nyaya Sanhita, 2023, for promoting enmity and discord amongst different communities with the sole purpose of making some marginal and imagined electoral gains, the Congress demanded that the Commission conduct a thorough investigation in these matters and direct the registration of a criminal case against all the individuals involved in the BJP’s vitriolic and blatantly violative electoral campaign in Maharashtra.

It also demanded that orders be passed banning the Prime Minister and the Union Home Minister from conducting any election-related activities for the remainder of the election period.

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