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Mumbai startup develops India’s first universal gene test for infectious disease

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Mumbai-based health-tech startup HaystackAnalytics has developed the first of its kind universal infectious diseases (ID) gene test to identify existing and emerging infections, the company said on Monday.

The company is supported by the Department of Science and Technology, as well as several private healthcare players.

To identify infections, the company deploys Next-Generation Sequencing (NGS) technology and Artificial Intelligence (AI), and also provides information on drug resistance to support and identify correct treatment options for patients.

The new Universal Infectious Diseases test will be rolled out with their current partners in a phased manner over the next three months, the company said in a statement.

It will initially be targeted at identifying and treating sepsis in Intensive Care Unit (ICU) patients, but gradually be made available to anyone suffering from a fever of unknown origin, by eradicating the need to conduct multiple tests.

The test comes at an opportune time, as Covid-19 pandemic highlights the need for better diagnostic technologies, appropriate antibiotic use, and the renewed importance of infection prevention strategies.

“The test enables rapid (within hours) and comprehensive (covering nearly all known bacterial and fungal pathogens) screening in a near to point of care deployment. Leveraging the power of next generation sequencing and AI, the team of scientists and engineers at Haystack has been able to eliminate the need for a redundant and expensive battery of tests, with a single test,” Dr. Anirvan Chatterjee, Co Founder and CEO of HaystackAnalytics, said.

“Our single point focus is to prevent each and every death caused due to treatable infections. Genomics has the potential to reduce trial and error in disease management and bring equality of access to high quality healthcare,” he added.

In the past, HaystackAnalytics had partnered with various diagnostic centers and over 20 hospitals including AIIMS, to introduce their sequencing-based clinical products for Tuberculosis and Covid in the past.

It is while working on two of the most debilitating infectious diseases — Tuberculosis and Covid — the company said it recognised the true burden of inaccurate diagnosis of infections in India and the world.

While the novel coronavirus infected and killed millions of people across the globe, there are various other infectious diseases that continue to plague India.

In particular, India accounts for the largest number of sepsis cases (11.3 million) and sepsis-related deaths (2.9 million) in the world, as per a global study published in the Lancet in 2020.

Despite having a wide range of antibiotics and antifungal medicines, sepsis is a life-threatening organ failure. It occurs when the body ends up injuring its own tissues and organs, in response to an infection, leading to shock, disability, multi-organ failure, and even death if left untreated in the early stages.

“A large proportion of these deaths can be avoided by early and accurate identification of the pathogen causing the infection. Haystack’s UID test has been developed to solve this exact problem,” Chatterjee said.

Maharashtra

Maharashtra drug racket exposed from MP police station, 4 arrested

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Mumbai: Police Crime Branch has claimed to have busted a drug smuggling gang in Maharashtra from Madhya Pradesh MC and arrested four accused involved in it from MP. All four are accused of running a drug racket in Maharashtra. On November 3, Imran alias Babu Khan (38), Waqas Abdul Rab Khan (30), Taqdeen Rafiq Khan (30), Kamlesh Ajay Chavan (23) from Nowpara were reported to have supplied drugs from Madhya Pradesh and sold them in Maharashtra. After this, the police arrested all four and seized more than one kg of MD, which is said to be worth more than Rs 2 crore, from their possession. This was informed by the DCP Crime Branch Amar Singh Jadhav here. He said that a big drug racket has been busted and there is a possibility of more arrests.

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Maharashtra

Two youths drown in Mumbai’s Mahim creek

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Mumbai: Two people jumped into the Mahim creek in Mumbai, due to which they drowned. The search for them is on. Today at around 12:20 pm, Irshad Asif Sheikh, a transgender, aged 22, residing at Lal Mati, Nargis Dutt Nagar, Bandra (West), Mumbai, and Qalander Altaf Khan, aged 20, residing at Lal Mati, Nargis Dutt Nagar, Bandra (West), were standing between a bridge in Bandra. During this, they had an argument and one jumped into the creek while the other also jumped into the water to save him.

During the argument, Irshad jumped into the water and Qalander Khan jumped after him to save him. However, both drowned in the water.

The search operation is on, so far no trace of both has been found. Teams are searching for both.

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Maharashtra

Sameer Wankhede targeted in The Baddest of Bollywood; Delhi High Court orders removal of objectionable content from controversial series in defamation case

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Mumbai: The Mumbai-Delhi High Court has strongly criticized Red Chillies Entertainment Shah Rukh Khan, Gauri Khan and others in the defamation case against NCB Zonal Director IRS officer Sameer Wankhede and said that artistic freedom does not mean mocking a person. After this, the High Court has ordered that the controversial footage related to Sameer Wankhede be removed from the controversial Netflix series The Bads of Bollywood. Sameer Wankhede had filed a petition in the High Court and pleaded that his character has been killed in The Bads of Bollywood and this series has been made to target him. The purpose is to humiliate and mock Sameer Wankhede. After watching some parts of this series, the High Court has ordered the removal of the controversial parts from the film.

Sameer Wankhede’s lawyer had told the court that the character portrayed in the film is a comparison to Sameer Wankhede and that this series has been created with the intention of tarnishing Wankhede’s image. The Bads of Bollywood is malicious, therefore, the above-mentioned controversial scenes and objectionable dialogues should be deleted from the series, on which the court has issued an order to delete the controversial and objectionable content and content. Earlier, while hearing Sameer Wankhede’s petition, the court had sent notices to Shah Rukh Khan’s Red Chillies, Netflix, Meta, and social media platforms and directed them to file a response. To this, Red Chillies had called the film and series a drama and made it clear that it had nothing to do with the facts. However, despite this, the Delhi High Court inquired whether a film drama does not mean that someone’s character is killed and said this, it reprimanded Shah Rukh Khan and the film company. Sameer Wankhede tried to prove through his argument that the character portrayed in the film resembles Sameer Wankhede and that this character has been portrayed in a negative way to target him and in this, an attempt has been made to make fun of Sameer Wankhede through this character, which has humiliated Wankhede, which the court has accepted and issued a directive to delete the objectionable and controversial content. This is a big success for Sameer Wankhede, while Shah Rukh Khan has suffered a huge setback.

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