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Mumbai startup develops India’s first universal gene test for infectious disease

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Mumbai-based health-tech startup HaystackAnalytics has developed the first of its kind universal infectious diseases (ID) gene test to identify existing and emerging infections, the company said on Monday.

The company is supported by the Department of Science and Technology, as well as several private healthcare players.

To identify infections, the company deploys Next-Generation Sequencing (NGS) technology and Artificial Intelligence (AI), and also provides information on drug resistance to support and identify correct treatment options for patients.

The new Universal Infectious Diseases test will be rolled out with their current partners in a phased manner over the next three months, the company said in a statement.

It will initially be targeted at identifying and treating sepsis in Intensive Care Unit (ICU) patients, but gradually be made available to anyone suffering from a fever of unknown origin, by eradicating the need to conduct multiple tests.

The test comes at an opportune time, as Covid-19 pandemic highlights the need for better diagnostic technologies, appropriate antibiotic use, and the renewed importance of infection prevention strategies.

“The test enables rapid (within hours) and comprehensive (covering nearly all known bacterial and fungal pathogens) screening in a near to point of care deployment. Leveraging the power of next generation sequencing and AI, the team of scientists and engineers at Haystack has been able to eliminate the need for a redundant and expensive battery of tests, with a single test,” Dr. Anirvan Chatterjee, Co Founder and CEO of HaystackAnalytics, said.

“Our single point focus is to prevent each and every death caused due to treatable infections. Genomics has the potential to reduce trial and error in disease management and bring equality of access to high quality healthcare,” he added.

In the past, HaystackAnalytics had partnered with various diagnostic centers and over 20 hospitals including AIIMS, to introduce their sequencing-based clinical products for Tuberculosis and Covid in the past.

It is while working on two of the most debilitating infectious diseases — Tuberculosis and Covid — the company said it recognised the true burden of inaccurate diagnosis of infections in India and the world.

While the novel coronavirus infected and killed millions of people across the globe, there are various other infectious diseases that continue to plague India.

In particular, India accounts for the largest number of sepsis cases (11.3 million) and sepsis-related deaths (2.9 million) in the world, as per a global study published in the Lancet in 2020.

Despite having a wide range of antibiotics and antifungal medicines, sepsis is a life-threatening organ failure. It occurs when the body ends up injuring its own tissues and organs, in response to an infection, leading to shock, disability, multi-organ failure, and even death if left untreated in the early stages.

“A large proportion of these deaths can be avoided by early and accurate identification of the pathogen causing the infection. Haystack’s UID test has been developed to solve this exact problem,” Chatterjee said.

Maharashtra

Mega Block Alert: Local Trains to be Rerouted & Delayed On Feb 23 For Maintenance Work, Check Details

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Mumbai: Central Railway announced a major change in the UP and Down fast local trains in the Central route for February 23. Meanwhile, Western Railway also announced a major mega block on the line. The jumbo block is carried out for maintenance work on signals and tracks, which will lead to rerouting and delays in train schedules.

Central Railway Rerouting Details

On the Thane to Kalyan route, Down Fast and Semi-Fast local trains departing from Chhatrapati Shivaji Maharaj Terminus (CSMT) Mumbai will be diverted to the Down Slow line between Thane and Kalyan stations. These trains will have additional halts at Kalva, Mumbra, and Diva stations, which will result in a delay of approximately 10 minutes in reaching their destinations.

Similarly, Up Fast and Semi-Fast trains departing from Kalyan towards CSMT will be rerouted onto the Up Slow line between Kalyan and Thane stations. They will also halt at Diva, Mumbra, and Kalva before merging onto the Up Fast line at Mulund station, causing a delay of around 10 minutes.

Western Railway’s Five-Hour Jumbo Block

On the Western line, a significant five-hour Jumbo Block has been scheduled on February 23, between Santacruz and Goregaon stations. From 10:00 AM to 3:00 PM, both Up and Down Fast lines due to maintenance work of tracks, signalling systems, and overhead equipment.

Trans-Harbour Line

According to railway officials, there will be no block on the Uran and Harbour routes.

However, services on the Trans-Harbour line will be temporarily suspended. Up Trans-Harbour services from Panvel, Nerul, and Vashi towards Thane starting with the 10:25 AM departure from Vashi and the 4:09 PM departure from Nerul will remain non-operational. Likewise, Down Trans-Harbour services from Thane to Vashi, Nerul, and Panvel, running from 10:35 AM to 4:07 PM, will also be suspended during this period.

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Maharashtra

Maha minority panel to seek shorter working hours for Muslim staff during Ramzan

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Mumbai, Feb 22: After Telangana and Andhra Pradesh permitted Muslim government employees to leave offices early during the fasting month of Ramzan, similar demands are now being raised in Maharashtra and other states.

Maharashtra Minority Commission Chairman Pyare Khan confirmed that the commission has received multiple applications requesting the state government to allow Muslim employees to leave work an hour early during Ramzan.

“We have received several requests from people asking for permission to leave offices an hour early during Ramzan. India is a great example of ‘Ganga Jamuna Tehzeeb,’ where people from different communities live together in harmony,” Khan told media.

He added that he plans to present this demand to Maharashtra Chief Minister Devendra Fadnavis through an official letter.

The demand follows orders issued by the Telangana and Andhra Pradesh governments, allowing Muslim employees, including teachers and contract workers, to leave work at 4 p.m. instead of the usual 5 p.m. from March 2 to March 30 to perform religious rituals.

“The government hereby permits all the employees who profess Islam, including teachers and persons hired on contract, out-sourcing basis, and Village/Ward Secretaries, to leave their offices/schools early by an hour before closing time on all working days during the Holy month of ‘Ramzan’ to perform necessary rituals,” read the Andhra Pradesh government order.

Similarly, the Telangana government order stated: “Government hereby permits all Muslim government employees/teachers/contract/out-sourcing/boards/corporations and public sector employees working in the state to leave their offices/schools at 4 p.m. during the holy month of Ramzan, i.e., from March 2 to 31, to offer necessary prayers, except when their presence is required due to exigencies of services.”

The demand is also gaining traction in Karnataka, where Pradesh Congress Committee (KPCC) Vice Presidents M.R.M. Hussain and Syed Ahmad recently wrote to Chief Minister Siddaramaiah, urging the state government to grant Muslim employees a one-hour exemption from duty to facilitate prayers and iftar.

However, the Karnataka government has yet to make a decision on the request.

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disaster

Massive Fire Breaks Out At Residential Building In Mumbai’s Marine Lines

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Mumbai: A massive fire broke out in Mumbai’s Marine Lines on Saturday. The blaze rupted on the top floor of a residential building, Marine Chambers. The building is located near Gol Masjid.

The fire broke out at around 12.30 pm on Saturday. After receiving information, several fire tenders reached the spot. Senior officials also rushed to the place where the blaze erupted.

Visuals of the fire also surfaced online. In the video, an envelope of black smoke could seen billowing out of the building. This led to panic among the locals.

A firefighting operation is currently underway.

The reason for the blaze is not yet known. There are no reports of any injuries.

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