General
Corbevax booster gives maximum protection, reveals Hyd hospital study
Amidst concerns of a new Covid wave in India following massive surge in China and other countries, research at AIG Hospitals here has revealed that Corbevax booster in individuals vaccinated with Covishield gives maximum protection against Omicron variants.
The scientific study has proved the immunity benefits of indigenous heterologous vaccine booster, Corbevax in combating Omicron variants.
The study titled “Heterologous booster dose with Corbevax following primary vaccination with Covishield enhances protection against SARS-CoV-2” has been published in the high-impact factor journal “Vaccines”.
Announcing the findings of the study, AIG Hospitals Chairman Dr D Nageshwar Reddy told media persons that the study was done on 250 healthcare workers who had received 2 doses of Covishield as the primary vaccine regimen not more than 6 months ago. None of the participants had any adverse events following the administration of Corbevax booster dose.
“We knew from our previous studies that mixed vaccines produce better immune response; therefore, when the government approved Corbevax to be given as a heterologous booster to individuals already vaccinated with Covishield, our aim was to determine how a different vaccine platform (protein-based) will impact the immune response especially in context of the Omicron variant,” he said.
Corbevax is an indigenously developed peptide-based vaccine which is different from the viral vector (Covishield) or the inactivated vaccine (Covaxin). The key difference is that Corbevax uses only a protein subunit of the virus replicated inside a yeast cell while the others are whole virus vaccines. The advantage of peptide-based vaccine is that it considerably reduces the risks of allergic and autoimmune responses making them safe for widespread usage.
Dr Reddy said the results further cemented their belief that mixed vaccines are absolutely safe. “The second aspect of the study was to measure the antibody response as well as the T-cell (memory cell) response at 30 days and then at 90 days to correctly estimate the overall protection against the circulating Omicron variant.
When estimating the effectiveness of a vaccine, both the antibody response and T-cell (Memory cell) response are essential.
“In our study, we compared the immune responses among those individuals who were given the same vaccine, i.e., Covishield (homologous group) as a booster and those who were given Corbevax as a booster (heterologous group). The S1/S2-spike protein IgG antibody levels and T/B Cell response of these groups were compared at 30 days and at 90 days. While the homologous and heterologous groups showed increased S1/S2-spike protein IgG antibody level at 30 days, the heterologous group (Corbevax as a booster) showed higher levels of antibodies at both 30 days and 90 days,” Dr Reddy said.
The study was undertaken when Omicron variants are circulating in India; therefore, it would be appropriate to say that heterologous booster (Corbevax) would be effective in combating any wave that is fueled by sub-variants of the Omicron.
High-risk group people should consider taking the booster dose and continue to take Covid appropriate precautions all the time especially when in public spaces.
Replying to queries, Dr Reddy said if a person has taken Covaxin double dose, he should also take Corbevax as the booster dose. “The booster dose should be from the other company as this gives more protection,” he said.
He noted that only 28 per cent of people in the country have taken booster dose. Corbevax is manufactured by Hyderabad-based Biological E.
Dr Reddy said that the vaccine is easy to manufacture and it is already available in the market at a price of Rs 250.
He suggested that China should also import Corbevax to save lives.
Dr Reddy also made it clear that there is no need for panic as the both the central and state governments are taking necessary measures and adequate stocks of vaccines and Remdesivir are available.
He believes that the number of Covid cases may increase over the next two months but from March next year, the situation will be normal.
He said people should wear masks while going in crowded places. He believes that the impact of the new variant of Omicron will not be severe.
Maharashtra
Internal Rift May Cost Samajwadi Party Dear: Political Turmoil in Ward 211 Involving MLA Rais Shaikh

Mumbai: The ongoing tension between Samajwadi Party (SP) Maharashtra president Abu Asim Azmi and the party’s own MLA Rais Shaikh has taken a serious turn and could prove politically costly for the party in Mumbai and Bhiwandi. What began as internal differences has now escalated into an open power struggle, just as the bugle for municipal corporation elections across Mumbai and Maharashtra has been sounded.
For the past several months, relations between Abu Asim Azmi and MLA Rais Shaikh have remained strained. Sources within the party claim that Azmi had decided to completely sideline Rais Shaikh and hand over key organisational responsibilities to Yusuf Abhrani, a former Congress leader who recently joined the Samajwadi Party. This move reportedly deepened the rift, with speculation rife that Rais Shaikh might even switch allegiance to Ajit Pawar’s camp or return to the Congress, as he felt marginalised within his own party.
The simmering internal conflict has now spilled into the open with the start of civic election preparations. Rais Shaikh had requested party leadership to allot municipal tickets to some of his close aides, but the Samajwadi Party leadership allegedly refused to give tickets to any of his supporters. Feeling politically cornered, Rais Shaikh responded by fielding several of his associates as independent candidates.
More significantly, Rais Shaikh is said to have played a key role in ensuring that his personal assistant, Waqar Khan, received a Congress ticket from Ward No. 211—a seat that was earlier considered a stronghold of the Samajwadi Party. With Congress now officially fielding Waqar Khan from this ward, SP risks losing a seat it was once confident of winning.
Political observers believe that ignoring Rais Shaikh could cost the Samajwadi Party heavily not only in Govandi but also in Bhiwandi, where multiple seats may be affected due to rebel candidates and divided votes. Meanwhile, Yusuf Abhrani—projected as Rais Shaikh’s replacement—has fielded his daughter-in-law against Geeta Gawli, daughter of Arun Gawli, a move that too appears to have weakened SP’s prospects in that constituency.
As factionalism deepens, the Samajwadi Party now faces the possibility of significant electoral losses in key urban pockets. Whether the leadership will attempt damage control or allow the rift to widen further remains to be seen, but one thing is clear: internal discord may prove more damaging than opposition attacks in the upcoming municipal elections.
Maharashtra
Bike theft gang busted in Mumbai, four theft cases solved, five bikes seized

Mumbai: Police has exposed a gang of motorcycle thieves in Mumbai and claimed to have seized the stolen motorcycles. On December 20, the police had registered a complaint about the theft of an active motorcycle from the New Link Road area in the Malad area of Mumbai. In the investigation of this crime, the police inspected the scene and examined 40 to 50 CCTV cameras installed around the place from where the motorcycle was stolen. The images of the thief who stole the motorcycle were captured in the camera. The accused was going towards Maloni with this motorcycle. The police investigated the matter day and night for two days and solved the case. In this case, the motorcycle thief Pratham Surendra, 18, was arrested. Two theft cases were registered against him in the Malad police station, one in VB Nagar, and one in Jogeshwari. This case has been solved on the initiative of Additional Commissioner North Shashi Kumar Meena, DCP Zone 11 Sandeep Jadhav. Five motorcycles have been seized as a result of this case and the police have claimed to have solved the mystery of the theft of four motorcycles in total. The police are investigating this matter further.
Maharashtra
Mumbai BMC Elections Samajwadi Party’s first list released but no decision on ward number 211

Mumbai: In the Mumbai municipal elections, Mahayoti and Maha Vikas Aghadi have not yet reached an electoral agreement, while the Congress Party, Samajwadi Party and AIMIM have released their first list of candidates for the municipal corporation. The Samajwadi Party has released the first list of 21 candidates, in which Zeb-un-Nisa Malik has been appointed as the candidate from 213, along with Shahzad Abrahani from 212. There is a tug of war going on in the Samajwadi Party over ward number 211, so the party has not announced its candidate for this ward. SP leader Raees Sheikh has also introduced his brother Salim Sheikh as a candidate for this ward. The Samajwadi Party has not yet taken any decision regarding the ticket in this ward, while the candidature of Raees Sheikh’s brother is also being opposed. Local women have opened a front against Raees Sheikh and have also submitted a claim for the SP candidacy. In such a situation, who will be given a candidate from 211 in the Samajwadi Party is still pending. Samajwadi Party had announced to separate from Maha Vikas Aghadi and contest the elections alone, while Uddhav and Raj Thackeray have also reached an electoral understanding. Along with this, Ajit Pawar and Sharad Pawar’s NCP is also in talks regarding an electoral understanding. If there is an electoral understanding between Ajit Pawar and Sharad Pawar, then the Congress party is ready to contest the elections alone, this has been claimed by Congress leader Jaya Witward. In the Mumbai BMC elections, every political party is trying to outdo each other, while the two brothers have formed an alliance on the issue of Marathi Manas and banners of Marathi Manas being united are also being displayed in Mumbai city.
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