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Corbevax booster gives maximum protection, reveals Hyd hospital study

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 Amidst concerns of a new Covid wave in India following massive surge in China and other countries, research at AIG Hospitals here has revealed that Corbevax booster in individuals vaccinated with Covishield gives maximum protection against Omicron variants.

The scientific study has proved the immunity benefits of indigenous heterologous vaccine booster, Corbevax in combating Omicron variants.

The study titled “Heterologous booster dose with Corbevax following primary vaccination with Covishield enhances protection against SARS-CoV-2” has been published in the high-impact factor journal “Vaccines”.

Announcing the findings of the study, AIG Hospitals Chairman Dr D Nageshwar Reddy told media persons that the study was done on 250 healthcare workers who had received 2 doses of Covishield as the primary vaccine regimen not more than 6 months ago. None of the participants had any adverse events following the administration of Corbevax booster dose.

“We knew from our previous studies that mixed vaccines produce better immune response; therefore, when the government approved Corbevax to be given as a heterologous booster to individuals already vaccinated with Covishield, our aim was to determine how a different vaccine platform (protein-based) will impact the immune response especially in context of the Omicron variant,” he said.

Corbevax is an indigenously developed peptide-based vaccine which is different from the viral vector (Covishield) or the inactivated vaccine (Covaxin). The key difference is that Corbevax uses only a protein subunit of the virus replicated inside a yeast cell while the others are whole virus vaccines. The advantage of peptide-based vaccine is that it considerably reduces the risks of allergic and autoimmune responses making them safe for widespread usage.

Dr Reddy said the results further cemented their belief that mixed vaccines are absolutely safe. “The second aspect of the study was to measure the antibody response as well as the T-cell (memory cell) response at 30 days and then at 90 days to correctly estimate the overall protection against the circulating Omicron variant.

When estimating the effectiveness of a vaccine, both the antibody response and T-cell (Memory cell) response are essential.

“In our study, we compared the immune responses among those individuals who were given the same vaccine, i.e., Covishield (homologous group) as a booster and those who were given Corbevax as a booster (heterologous group). The S1/S2-spike protein IgG antibody levels and T/B Cell response of these groups were compared at 30 days and at 90 days. While the homologous and heterologous groups showed increased S1/S2-spike protein IgG antibody level at 30 days, the heterologous group (Corbevax as a booster) showed higher levels of antibodies at both 30 days and 90 days,” Dr Reddy said.

The study was undertaken when Omicron variants are circulating in India; therefore, it would be appropriate to say that heterologous booster (Corbevax) would be effective in combating any wave that is fueled by sub-variants of the Omicron.

High-risk group people should consider taking the booster dose and continue to take Covid appropriate precautions all the time especially when in public spaces.

Replying to queries, Dr Reddy said if a person has taken Covaxin double dose, he should also take Corbevax as the booster dose. “The booster dose should be from the other company as this gives more protection,” he said.

He noted that only 28 per cent of people in the country have taken booster dose. Corbevax is manufactured by Hyderabad-based Biological E.

Dr Reddy said that the vaccine is easy to manufacture and it is already available in the market at a price of Rs 250.

He suggested that China should also import Corbevax to save lives.

Dr Reddy also made it clear that there is no need for panic as the both the central and state governments are taking necessary measures and adequate stocks of vaccines and Remdesivir are available.

He believes that the number of Covid cases may increase over the next two months but from March next year, the situation will be normal.

He said people should wear masks while going in crowded places. He believes that the impact of the new variant of Omicron will not be severe.

Maharashtra

Samajwadi Party is not part of Mumbai Municipal Corporation Vikas Aghadi: Abu Asim Azmi

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Mumbai: The Samajwadi Party will not enter into an electoral alliance with the Maha Vikas Aghadi in the Municipal Corporation (BMC) elections, not will it be part of this alliance. Those who objected to the release of innocent Muslims imprisoned for 19 years but remained silent on the release of the accused in the Malegaon blasts. Those who express pride in the demolition of the Babri Masjid, take the names of Lord Ram and Lord Vishwanath, but call the holy water of the Sangam smelly and make Uttar Bharatiyas and North Indians a target for violence. This is a province where the Pawars go to do their country’s panddan. Those belonging to such provinces insult and subject North Indians and Biharis to violence.

If such people are part of the Maha Vikas Aghadi, the Samajwadi Party will never be part of it.

The Samajwadi Party does politics of justice, secularism, constitutional values ​​and Ganga-Jamuni culture. Therefore, we cannot be part of any alliance that includes forces that spread hatred and divide the country. This kind of explanation has been given by Mumbai Maharashtra Samajwadi Party leader and MLA Abu Asim Azmi. Elections are approaching, in such a situation, Mahayoti and Maha Vikas Aghadi are very serious about their allied parties. In such a situation, the Samajwadi Party has clearly refused to enter into an understanding with Maha Vikas Aghadi and has called it biased. Now there is curiosity about the expected entry and entry of MNS in Maha Vikas. In such a situation, the Samajwadi Party has denied it and said that it is unable to participate in the elections with those who incite violence on the basis of regionalism.

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Maharashtra

Controversy over ban on photography in the guise of Shivaji Maharaj at Vasai Fort, verbal clash with non-Marathi guard, attempt to create Hindi-Marathi controversy

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Mumbai: The Marathi-non-Marathi conflict in the ancient fort of Mumbai’s Vasai has once again intensified the atmosphere. Due to which tension has spread in the area and after allegations of obscenity and immoral behavior of young couples in the fort, the police have issued an alert around the fort. A Marathi-Hindi conflict broke out in the ancient fort in Vasai Virar when a non-Marathi migrant guard opposed a photo shoot in the guise of a Maharaj, after which the video went viral on social media and now there is a flood of comments on it. The migrant guards of Bhayander Center stopped the artists who were getting a photo shoot and filming in the guise of Chhatrapati Shivaji Maharaj, Vasai Fort, which is located within the limits of Vasai Police Station.

Social media influencer actor Rupesh Dilip Halawale has shared an incident that happened to him on social media. Rupesh Halawale was getting a photo shoot in the guise of Chhatrapati Shivaji Maharaj in the Vasai Fort. However, a person present there stopped them from taking photos. Moreover, since he was a migrant, he could not speak Marathi. On this, Rupesh consoled the man.

In the video, Rupesh first says in Hindi to a man dressed as a security guard, “I respected you by speaking Hindi, then you should also respect me by living in Maharashtra and speaking Marathi.” Then he asks him, “How many years have you been working here? Why haven’t you learned Marathi in all these years? Why don’t you know Marathi? When will you learn Marathi?” Then he shows the man’s identity card. On which the name of Brijesh Kumar Gupta is written.

Then Rupesh says, “This man works as a security guard in Vasai Fort. When we were taking photos in the attire of Chhatrapati Shivaji Maharaj, he stops the Marathi people and says in a very adamant manner, I don’t know Marathi.”

Then the security guard brings another person. On this too Rupesh says, “You want to be famous.. You have brought this man here to do bhai giri, if you do not respect Chhatrapati Shivaji Maharaj here then you will have to leave this job, there is a shooting of Chhatrapati Shivaji Maharaj here. We should know what is the condition of the forts, how was the fort built, what do couples do when they come here”.
“It is okay for some people to come with their mothers and sisters. But when some people come to do inappropriate and immoral things, what do you do, your eyes get wide open.

“Here we do not do any nonsense, we do not wear Maharaj’s clothes and drink alcohol. We are just taking pictures. When the couples are doing nonsense, you do not say anything to them. This will not be tolerated. Then you respect them, and start learning Marathi from tomorrow.

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Maharashtra

Mumbai drivers should be given 25% discount on purchase and conversion of electric vehicles: Raees Shaikh

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Mumbai: Samajwadi Party MLA from Bhiwandi East Raees Shaikh has written a letter to the state transport department on the draft Motor Vehicle Aggregators Rules, 2025, suggesting that drivers be given a 25 per cent subsidy on the cost of converting to an electric vehicle (EV) and it should be provided from the Driver Welfare Fund. The transport department had published the draft rules in this regard on October 9 and the last date for submission of suggestions and objections is October 26.

MLA Raees Shaikh said that to increase the income of drivers, the daily working hours limit should be increased, passengers should be given a fixed period to cancel the ride without being charged a fine, a government grievance redressal portal should be created, delay compensation should be given to passengers, medical and psychological tests of drivers should be conducted and regular testing of GPS should be done from funds.

Raees Shaikh, in a letter to the Transport Commissioner, suggested a phased transition to EVs to promote sustainable transport in draft Rules 18 and 20. Since drivers will not be able to bear the heavy costs, these changes will be possible if a 25% subsidy is provided through the Driver Welfare Fund. Raees Shaikh has suggested major changes in the ride cancellation policies under Rule 17. Passengers should be fined only if the driver comes within 200 meters of the pick-up point. In addition, passengers should be given a grace period of 2-3 minutes to cancel after booking without any fee.

The cost of fines due to software glitches or GPS errors should be borne by the aggregators, not the drivers. In case of vehicle malfunction, passengers should be refunded 10% of the fare if there is a delay beyond the permissible limit. MLA Raees Shaikh has recommended that there should be a government portal for complaints that are not resolved for more than seven days.

On driver welfare under Rule 10, Raees Shaikh has insisted that the cost of mandatory medical and psychological tests should be borne entirely by the aggregators. The limit of daily working hours should be increased to 14 hours. This will help increase the income of drivers.

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