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Study explores role of immune cells in cancer treatment outcomes

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New Delhi, Feb 18: The immune systems of cancer patients may play a significant role in their treatment outcomes, according to a study on Tuesday.

In the study, researchers at the University College London and the Francis Crick Institute found that cancer patients with a higher number of immune cells in their blood have a better survival rate.

They used a pioneering technique — Immune Lymphocyte Estimation from Nucleotide Sequencing (ImmuneLENS), which enables researchers to calculate the proportion of T cells and B cells (types of immune cells) from whole genome sequencing (WGS) data.

The team analysed over 90,000 WGS samples — both of healthy individuals and cancer patients. The findings described in the journal Nature Genetics showed that cancer patients had a lower proportion of T cells circulating in the blood compared to healthy individuals.

Further, T cell proportion was found to be a strong predictor of cancer outcomes, with higher proportions associated with 47 per cent fewer deaths over five years after surgery.

This effect was still significant when accounting for age, cancer stage, and across all cancer types — biological markers which can be added to current genetic diagnostic tests to help clinicians with more information on which to base treatment plans, said the researchers.

Professor Nicholas McGranahan, senior author of the study from UCL Cancer Institute, said while most immune system analysis until now has focused on the tumour itself, with the new tool, doctors “may be able to predict how long a cancer patient will survive better than the number of T cells in the tumour alone”.

The study also showed that in people with cancer, particularly males, the proportion of immune cells in the blood diminishes faster. However, the reason behind these sexual differences remains unclear.

They also observed that individuals who were seemingly healthy at the time their sample was taken for sequencing, who subsequently went on to develop cancer, had below-average levels of B cells in their blood.

This could be because of undiagnosed early-stage cancer, or pre-cancerous changes to the immune system that could potentially have been an early sign of disease or even a factor in cancer development.

This information could be used in the future for cancer early detection or to help clinicians understand how the patient may respond to treatment, said the researchers.

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One dead, 12 infected in Legionnaires’ disease outbreak in Sydney

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Sydney, April 17: A person has died and 12 others have been infected after contracting Legionnaires’ disease in an outbreak linked to central Sydney, the Department of Health in the Australian state of New South Wales said on Thursday.

There are now 12 confirmed cases of Legionnaires’ disease in people who spent time in central Sydney between March 13 and April 5, up from the six cases that had been diagnosed as of April 10, the department said.

It said that one of the confirmed cases died in the hospital. Of the 12 reported cases, 11 have been hospitalised for treatment.

NSW Health on Thursday urged anyone who spent time in central Sydney and surrounding areas in late March or early April to be aware of symptoms of Legionnaires’ disease, including fever, chills, a cough and shortness of breath.

Legionnaires’ disease is a form of pneumonia caused by infection with Legionella bacteria, which is found naturally in fresh water. NSW Health said that symptoms can develop up to 10 days after exposure, Xinhua news agency reported.

“Outbreaks sometimes occur when bacteria from environmental sources such as cooling towers atop large buildings become contaminated,” Vicky Sheppeard, director of the southeast Sydney local public health unit, said in a statement.

“NSW Health continues to work closely with the City of Sydney to identify, inspect and sample any cooling towers in the CBD potentially implicated in the outbreak. To date, over 165 cooling towers have been inspected and tested,” she said.

According to the World Health Organisation, the Legionnaires’ disease mortality rate can be as high as 80 per cent in untreated immunosuppressed patients.

Most people catch Legionnaires’ disease by inhaling the bacteria from water or soil. Older adults, smokers, and people with weakened immune systems are particularly susceptible to Legionnaires’ disease.

Although Legionnaires’ disease primarily affects the lungs, it occasionally can cause infections in wounds and in other parts of the body, including the heart.

A mild form of Legionnaires’ disease — known as Pontiac fever — can produce fever, chills, headache and muscle aches. Pontiac fever doesn’t infect your lungs, and symptoms usually clear within two to five days.

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Valve disorders may raise risk of severe heartbeat condition

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New York, April 15: People with a certain heart valve abnormality may be at an increased risk of developing severe heart rhythm disorders also known as arrhythmias, according to a study on Tuesday.

Researchers from the Karolinska Institutet in Sweden showed that the valve abnormality called Mitral annular disjunction (MAD) increases the risk of ventricular arrhythmias — a dangerous type of heart rhythm disorder that, in the worst case, can lead to cardiac arrest.

The team found that the risk of arrhythmias persists even after successful valve surgery.

MAD is often associated with a heart disease called mitral valve prolapse, which affects 2.5 per cent of the population and causes one of the heart’s valves to leak. This can lead to blood being pumped backward in the heart, causing heart failure and arrhythmias. The disease can cause symptoms such as shortness of breath and palpitations.

The study, published in the European Heart Journal, showed that people with MAD were more likely to be female and were on average eight years younger than those without MAD.

They also had more extensive mitral valve disease.

Although the surgery was successful in correcting MAD, these patients had more than three times the risk of ventricular arrhythmias during five years of follow-up compared to patients without preoperative MAD.

“Our results show that it is important to closely monitor patients with this condition, even after a successful operation,” said Bahira Shahim, Associate Professor at the Department of Medicine, Solna, Karolinska Institutet.

In the study, the researchers investigated the risk of cardiac arrhythmias in 599 patients with mitral valve prolapse who underwent heart surgery at Karolinska University Hospital between 2010 and 2022.

The study aims to further explore new hypotheses such as that MAD causes permanent changes in the heart muscle over time, and that MAD is a sign of an underlying heart muscle disease

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Mumbai Tragedy: Elderly Man Suffers Heart Attack In Andheri; Dies Before Reaching Hospital Due To Unavailability Of Ambulance

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Mumbai: A 73-year-old Andheri resident, Steven Fernandes, suffered a fatal heart attack in the early hours of Thursday as his family struggled to arrange an ambulance in time. Despite living just five minutes from a private hospital and 20 minutes from the civic-run Dr. R.N. Cooper Hospital, critical minutes were lost due to an unresponsive emergency service and delays from a private ambulance.

“At 2 am, my husband and I were frantically calling every number we could find for an ambulance,” Mohua Gupta, Fernandes’ daughter-in-law, told media. Their first attempt was to dial 108, the state emergency response service, but the call either didn’t go through or connected to 103, the police helpline. With no help forthcoming, the family turned to an online search, which led them to a private ambulance vendor from Andheri East.

Relief Turns Into Distress Due To Ambulance Delay

Relieved that someone had agreed to come, the family focused on Fernandes, who lay unconscious. Moving him without assistance was impossible, as he weighed over 100 kg. However, their relief turned to distress when the private ambulance took over 40 minutes to arrive, despite the lack of traffic at that hour.

Upon arrival, the ambulance lacked essential medical equipment. “There was only a driver and a helper, no paramedic, no physician, not even a stretcher. Just a rubber mat for him to lie on,” Gupta told media. There was also no oxygen supply or masks, which are critical for cardiac emergencies.

Adding to their frustration, before even shifting the patient, the ambulance service sent a text message demanding Rs 5,500 for the trip. “We were shocked. After protesting, they reduced the charge to Rs 2,500, but we had no choice but to pay,” she recalled.

Patient Passed Away Before Reaching Hospital

Shortly after the private ambulance left, the family dialed 108 again. This time, the call was diverted to Cooper Hospital, and an official ambulance was dispatched. However, it took another 30 minutes to arrive. By then, the crucial Golden Hour, the first 60 minutes after a heart attack, when timely medical intervention can be life-saving, had passed. Fernandes’ pulse had flatlined by the time he reached the hospital.

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