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Corbevax booster gives maximum protection, reveals Hyd hospital study

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 Amidst concerns of a new Covid wave in India following massive surge in China and other countries, research at AIG Hospitals here has revealed that Corbevax booster in individuals vaccinated with Covishield gives maximum protection against Omicron variants.

The scientific study has proved the immunity benefits of indigenous heterologous vaccine booster, Corbevax in combating Omicron variants.

The study titled “Heterologous booster dose with Corbevax following primary vaccination with Covishield enhances protection against SARS-CoV-2” has been published in the high-impact factor journal “Vaccines”.

Announcing the findings of the study, AIG Hospitals Chairman Dr D Nageshwar Reddy told media persons that the study was done on 250 healthcare workers who had received 2 doses of Covishield as the primary vaccine regimen not more than 6 months ago. None of the participants had any adverse events following the administration of Corbevax booster dose.

“We knew from our previous studies that mixed vaccines produce better immune response; therefore, when the government approved Corbevax to be given as a heterologous booster to individuals already vaccinated with Covishield, our aim was to determine how a different vaccine platform (protein-based) will impact the immune response especially in context of the Omicron variant,” he said.

Corbevax is an indigenously developed peptide-based vaccine which is different from the viral vector (Covishield) or the inactivated vaccine (Covaxin). The key difference is that Corbevax uses only a protein subunit of the virus replicated inside a yeast cell while the others are whole virus vaccines. The advantage of peptide-based vaccine is that it considerably reduces the risks of allergic and autoimmune responses making them safe for widespread usage.

Dr Reddy said the results further cemented their belief that mixed vaccines are absolutely safe. “The second aspect of the study was to measure the antibody response as well as the T-cell (memory cell) response at 30 days and then at 90 days to correctly estimate the overall protection against the circulating Omicron variant.

When estimating the effectiveness of a vaccine, both the antibody response and T-cell (Memory cell) response are essential.

“In our study, we compared the immune responses among those individuals who were given the same vaccine, i.e., Covishield (homologous group) as a booster and those who were given Corbevax as a booster (heterologous group). The S1/S2-spike protein IgG antibody levels and T/B Cell response of these groups were compared at 30 days and at 90 days. While the homologous and heterologous groups showed increased S1/S2-spike protein IgG antibody level at 30 days, the heterologous group (Corbevax as a booster) showed higher levels of antibodies at both 30 days and 90 days,” Dr Reddy said.

The study was undertaken when Omicron variants are circulating in India; therefore, it would be appropriate to say that heterologous booster (Corbevax) would be effective in combating any wave that is fueled by sub-variants of the Omicron.

High-risk group people should consider taking the booster dose and continue to take Covid appropriate precautions all the time especially when in public spaces.

Replying to queries, Dr Reddy said if a person has taken Covaxin double dose, he should also take Corbevax as the booster dose. “The booster dose should be from the other company as this gives more protection,” he said.

He noted that only 28 per cent of people in the country have taken booster dose. Corbevax is manufactured by Hyderabad-based Biological E.

Dr Reddy said that the vaccine is easy to manufacture and it is already available in the market at a price of Rs 250.

He suggested that China should also import Corbevax to save lives.

Dr Reddy also made it clear that there is no need for panic as the both the central and state governments are taking necessary measures and adequate stocks of vaccines and Remdesivir are available.

He believes that the number of Covid cases may increase over the next two months but from March next year, the situation will be normal.

He said people should wear masks while going in crowded places. He believes that the impact of the new variant of Omicron will not be severe.

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Mumbai Metro 2A & 7 Connecting Andheri To Dahisar Records Highest 2,87,073 Daily Ridership

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Mumbai: Amid heavy rainfall, the Mumbai Metro had an significant achievement. The Metro 2A and 7 Lines connecting Andheri to Dahisar surpassed highest daily ridership, reaching to 2,87,073 number of passengers the Maha Mumbai Metro Operations Corporation Limited (MMOCL) informed on Thursday.

“We are thrilled to share that Maha Mumbai Metro has proudly surpassed highest daily ridership, reaching an incredible 2,87,073 passengers on Mumbai Metro Line 2A & 7! Even amidst heavy rain, Maha Mumbai Metro remained your steadfast companion, ensuring seamless journeys for all.” the MMOCL posted on its official X handle.

MMOCL also said that it operated two extra services one each from Gundavali & Andheri West, whereas, Monorail operated six services to accommodate and effectively manage the surge in ridership.

However, the activist continue to highlight that the ridership of Mumbai Metro is at least 50 per cent less than planned and expected by the authorities.

In August this year, Mumbai’s first Metro line- the Ghatkopar-Andheri-Versova route achieved a record of carrying more thann 500,000 commuters in a single day. On August 13, 2024, Mumbai Metro One carried 500,385 commuters, surpassing the pre-covid ridership, the authorities informed.

“This is the first time ridership of Mumbai Metro One has crossed milestone figure of 500,000 without impact of external factors. There is only one occasion when ridership of Mumbai Metro One had crossed 5 lakh when BEST buses went on strike for 9 days (8 January to 16 January 2019)”, the Metro One had said in its press statement.

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‘Spider-Man’ Spotted Begging At Kalyan Railway Station

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An influencer posed as a man begging in a Spiderman costume at Kalyan Junction. The incident was staged for a reel, which the influencer posted on Instagram sooner. It showed ‘Spiderman From Mumbai’ sitting outside the railway station and seeking money from passersby. The caption of the reel, read in a beggar tone’s, “Spider-Man ko dedo bhai koi.”

The video opened showing the man sitting below the stairs of the railway station. He was seen wearing a Spider-Man costume to capture the attention of train passengers towards him. he repeatedly extended his hand forward begging for some money while being seated at the railway premises.

It wasn’t a real case of someone begging by wearing the superhero costume, but an act performed by the Instagram-based content creator for the craze of reels. As he performed as a beggar there, many people looked at him and one of them also approached him with some money. The reel recorded people at the railway station witnessing the reel act. One of the persons there stepped into the video to offer a coin to the ‘Spider-Man’ beggar.

This video is now going viral on Instagram. It was uploaded on the online platform in August, however, it has reached netizens and caught their attention in the recent days. So far, the reel, which shows the influencer posing as a beggar dressed up in a superhero costume, has attracted 2.8 million views and more than one lakh likes. People reacted to the video and hilariously wrote, “Spider man no money at home.” “We got Spider-Man in kalyan before GTA,” they added.

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Pongal 2024: Mumbai Celebrates Harvest Festival Reflecting Rich Tamil Culture

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Nearly 2000 people participated in Pongal festivities in and around Antop Hill on Monday. Mass Pongal celebration was carried out across various locations of the Sion Koliwada constituency and was facilitated by MLA Captain R Tamil Selvan who continues to organise these events embracing the harvest season and Tamil culture for more than a decade now.

In a beautiful display of cultural richness, locals dressed in traditional attires prepared Pongal reciting folk songs, raising the festival mood. The event saw them setting up their Pongal pots in the midst of sugarcane, flowers, and rangolis. The celebration was notably marked at the Antop Hill Cement Ground with about a thousand people lifting the festival spirit on the auspicious day. Other areas that observed Pongal on a grand scale included New 90 Feet Road, Kamaraj Nagar, Vijay Nagar, and the Malai Mariamman temple in Naik Nagar among a few others.

Captain Selvan was seen visiting the spots and joining the public in the celebration. “Pongal is associated with agriculture. Tamilians of various religious beliefs celebrate this festival together without any discrimination. This is the significance of Pongal,” he said while extending Pongal greetings.

The event was not confined to only the Tamil-speaking people celebrating the occasion as it saw women from diverse cultural backgrounds mark the festival. While Tamilians gathered there to celebrate Pongal, others enjoyed the Makar Sankranti festivities in the region with similar rituals involving boiling water and preparing food in their pots.

Pongalo Pongal” chants were heard during the celebration as women prayed to seek prosperity for their families while boiling and expecting their pots to overflow with the Pongal preparation.

Throwing more light on the harvest festival, the MLA acknowledged that the first dam built in the world was built by Karikala, a Tamilian. “Tamilians introduced the concept of building dams to stop running (river) water and distribute it for agricultural usage. Karikala from the Chola Dynasty constructed the Kallanai Dam over the Kaveri River running in Trichy.”

Several people admire the Tamil language and its treasurable culture, including PM Narendra Modi who recently inaugurated the Kashi Tamil Sangamam at Namo Ghat in Varanasi and mentioned about Pongal and remembered prominent Tamil personalities like Subramania Bharathiyar, Bharathidasan, and Thiruvalluvar.

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