health
Study explores role of immune cells in cancer treatment outcomes

New Delhi, Feb 18: The immune systems of cancer patients may play a significant role in their treatment outcomes, according to a study on Tuesday.
In the study, researchers at the University College London and the Francis Crick Institute found that cancer patients with a higher number of immune cells in their blood have a better survival rate.
They used a pioneering technique — Immune Lymphocyte Estimation from Nucleotide Sequencing (ImmuneLENS), which enables researchers to calculate the proportion of T cells and B cells (types of immune cells) from whole genome sequencing (WGS) data.
The team analysed over 90,000 WGS samples — both of healthy individuals and cancer patients. The findings described in the journal Nature Genetics showed that cancer patients had a lower proportion of T cells circulating in the blood compared to healthy individuals.
Further, T cell proportion was found to be a strong predictor of cancer outcomes, with higher proportions associated with 47 per cent fewer deaths over five years after surgery.
This effect was still significant when accounting for age, cancer stage, and across all cancer types — biological markers which can be added to current genetic diagnostic tests to help clinicians with more information on which to base treatment plans, said the researchers.
Professor Nicholas McGranahan, senior author of the study from UCL Cancer Institute, said while most immune system analysis until now has focused on the tumour itself, with the new tool, doctors “may be able to predict how long a cancer patient will survive better than the number of T cells in the tumour alone”.
The study also showed that in people with cancer, particularly males, the proportion of immune cells in the blood diminishes faster. However, the reason behind these sexual differences remains unclear.
They also observed that individuals who were seemingly healthy at the time their sample was taken for sequencing, who subsequently went on to develop cancer, had below-average levels of B cells in their blood.
This could be because of undiagnosed early-stage cancer, or pre-cancerous changes to the immune system that could potentially have been an early sign of disease or even a factor in cancer development.
This information could be used in the future for cancer early detection or to help clinicians understand how the patient may respond to treatment, said the researchers.
health
India takes lead in extreme heat risk management under PM Modi’s leadership

New Delhi, June 7: India has taken a proactive and forward-thinking approach to extreme heat risk management under the leadership of Prime Minister Narendra Modi, said Dr PK Mishra, Principal Secretary to the Prime Minister.
Delivering the keynote address during the Special Session on Extreme Heat Risk Governance in Geneva, he underlined that rising temperatures posing a systemic risk to public health, economic stability, and ecological resilience.
“India welcomes the United Nations Office for Disaster Risk Reduction’s (UNDRR) initiative to advance the Common Framework for Extreme Heat Risk Governance as a platform for shared learning, guidance, and collaboration,” he told the gathering, according to a Prime Minister’s Office (PMO) statement on Saturday.
Dr Mishra pointed out that India has moved beyond disaster response toward integrated preparedness and mitigation strategies. Since 2016, the National Disaster Management Authority (NDMA) has developed comprehensive national guidelines on heatwave management, revised in 2019, which laid the foundation for decentralised Heat Action Plans (HAPs).
He acknowledged the pioneering ‘Ahmedabad Heat Action Plan’, which demonstrated how early warnings, inter-agency coordination, and community outreach can save lives.
“Over 250 cities and districts across 23 heat-prone states have operational Heat Action Plans, supported by NDMA’s advisory, technical, and institutional mechanisms”, said the Principal Secretary, underscoring that strengthened surveillance, hospital readiness, and awareness campaigns have significantly reduced heatwave-related mortality.
India’s approach is whole-of-government and whole-of-society, engaging ministries from health, agriculture, urban development, labour, power, water, education, and infrastructure.
“Extreme heat deeply impacts communities, and India has actively incorporated traditional wisdom and local experiences into its response”, said Dr Mishra.
He noted that schools have become catalysts for behavioural change, educating children about climate resilience. He also emphasised that hospitals and primary health centres must be strengthened to ensure swift and effective emergency responses.
Outlining India’s transition from a preparedness-only approach to long-term heatwave mitigation, including cool roof technologies, passive cooling centres, urban greening, and the revival of traditional water bodies, Mishra affirmed that India is integrating Urban Heat Island (UHI) assessments into city planning.
He called for a global focus on developing a localised heat-humidity index based on real-time data to enhance early warning systems, advancing building technologies and passive cooling innovations that are affordable and culturally appropriate and addressing equity concerns, as extreme heat disproportionately affects women, outdoor workers, the elderly, and children.
health
Study shows how Covid virus shields itself during replication

New Delhi, June 6: US researchers have identified a mechanism that SARS-CoV-2 — the virus that causes Covid-19 — uses to protect itself inside the body as it works to replicate and infect more cells.
Without this protective mechanism, viral infection is dramatically reduced, said the team from the Texas Biomedical Research Institute and the University of Chicago.
The finding, published in the journal Nature Communications, not only provides a potential target for new Covid therapies but also offers insights that could inform future vaccine and antiviral development.
The study builds on earlier work from Texas Biomed that identified ORF3a, a type of viral protein most important for the virus’s pathogenicity, or ability to cause disease.
Specifically, the team found that SARS-CoV-2 ORF3a appears to play a vital role in protecting structural proteins, most notably the spike protein that facilitates spread into other cells, as they are assembled on the surface of viral particles.
It does this by driving the formation of a dense group of proteins that surround the spike protein and provide protection while in transit, much like security detail protecting a person or an armoured vehicle carrying cash to the bank, the researcher said.
Jueqi Chen, Assistant Professor at the University of Chicago, termed these protective complexes “3a dense bodies” or 3DBs for short.
It appears that 3DBs help prevent the spike protein from being cut into smaller components.
When ORF3a is missing, these 3DBs fail to form, and the spike protein often arrives damaged, severely impairing the nascent virus’s ability to infect new cells, the expert said.
“ORF3a could therefore be a good target for drugs to block the virus,” said Luis Martinez-Sobrido, Professor at Texas Biomed.
“This discovery could also be instrumental for vaccine development, as we illustrated previously,” Martinez-Sobrido added.
health
World Environment Day: Ministers call to stop plastic pollution, embrace sustainability

New Delhi, June 5: Union Ministers on World Environment Day on Thursday urged citizens to put an end to plastic pollution and embrace sustainability while also planting more trees for a greener and cleaner future.
World Environment Day is observed every year on June 5. The theme this year, ‘Beat Plastic Pollution’ aims to end plastic pollution.
“As we mark #EnvironmentDay today, let’s reaffirm our commitment to protecting our planet and ensuring sustainability for all living beings. Always remember nature protects when protected,” said Bhupender Yadav, Union Minister for Environment, Forest and Climate Change (MoEFCC), in a post on social media platform X.
“On World Environment Day, let us renew our commitment to protect the planet by planting more trees, reducing pollution, conserving resources, and embracing sustainability. Together, our small steps can create a greener, healthier, and more hopeful future for all,” added Pralhad Joshi, Union Minister of Consumer Affairs.
Globally, an estimated 11 million tonnes of plastic waste leak into aquatic ecosystems each year, while microplastics accumulate in the soil from sewage and landfills, due to the use of plastics in agricultural products.
Jitendra Singh, Union Minister of State (Independent Charge) for Science and Technology stated that India “reiterates its strong commitment to beat plastic pollution through proactive policies, sustainable practices and mass awareness. Together, let’s restore ecosystems, conserve biodiversity, and build a greener, cleaner future”.
“Let us take a pledge on this Environment Day – stop plastic pollution, live in harmony with nature, and create a greener, cleaner, and safer earth for future generations,” added Kirti Vardhan Singh, Union Minister of State for MoEFCC.
Besides choking the planet, plastic pollution permeates even our bodies in the form of microplastics and poses several health risks.
“Plastic pollution is choking our planet – harming ecosystems, well-being, and the climate. Plastic waste clogs rivers, pollutes the ocean, and endangers wildlife,” said UN Secretary-General António Guterres.
“And as it breaks down into smaller and smaller parts, it infiltrates every corner of Earth: from the top of Mount Everest to the depths of the ocean; from human brains; to human breastmilk,” he added, calling for a movement for urgent change.
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