Tech
1st malaria vaccine shows promise against rising cases: Report 

New Delhi, Dec 19: The first blood-stage malaria vaccine RH5.1/Matrix-M has the potential to be a component within a developing malaria vaccine strategy, said a report on Thursday.
The report by GlobalData, a data and analytics company, showed that there are 11 other malaria vaccines currently in Phase II development.
As per a recent study by researchers in Burkina Faso and the UK, RH5.1/Matrix-M is safe, effective, and highly immunogenic.
The double-blind, randomised, controlled, phase 2b trial, analysed 361 children between the ages of 5 and 17 months showed that RH5.1/Matrix-M is 55 per cent effective against clinical malaria when administered in a delayed third-dose regimen at 0, 1, and 5 months.
Further, the vaccine demonstrated over 80 per cent efficacy against high levels of malaria parasites, which indicates the vaccine would be effective at preventing severe disease. RH5.1/Matrix-M was found to be generally safe and well-tolerated, with no serious adverse events being reported, revealed the findings published in The Lancet Infectious Diseases.
“RH5.1/Matrix-M has the potential to be the first blood-stage malaria vaccine brought to market. This could be a much-needed addition to the currently available malaria vaccines and provide an important second line of defense for those most at risk of contracting malaria,” said Stephanie Kurdach, Infectious Disease Analyst at GlobalData.
Malaria is a mosquito-borne disease, caused by parasitic Plasmodium protozoans, spread primarily through the bite of an infected female Anopheles mosquito. Typically, the symptoms can range from fever, chills, and headache to confusion, seizures, and difficulty breathing.
Kurdach noted that although there is progress and some nations have been certified as malaria-free, the burden of malaria remains high, particularly within the World Health Organization’s (WHO) African Region.
There are currently only two malaria vaccines, that are WHO prequalified and recommended for use in children: GSK’s Mosquirix and Serum Institute of India’s R21/Matrix-M.
These vaccines work to intercept malaria infection by targeting the early sporozoite stage of the parasite.
However, as immunity wanes with time, sporozoites can infect the liver and lead to blood-stage clinical malaria infection.
The development of a blood-stage malaria vaccine would replace these vaccines as well provide a second line of defense.
“There are 11 other malaria vaccines currently in Phase II development, including pre-erythrocytic vaccines and blood-stage vaccines from manufacturers such as BioNTech, GSK, the National Institute of Allergy and Infectious Diseases (NIAID), and Vac4All SAS,” Kurdach said.
“No new malaria vaccines are in Phase III development or pre-registration at this time,” she added.
Business
Jupiter Wagons’ net profit falls nearly 2 pc in Q4, revenue slips

Mumbai, May 19: Railway wagons and components manufacturer Jupiter Wagons on Monday reported a decline of 1.9 per cent in its net profit at Rs 103 crore in Q4 FY25, down from Rs 105 crore in the same period last fiscal.
The profit before tax (PBT) also declined by 8.26 per cent year-on-year (YoY) to Rs 127.47 crore from Rs 138.95 crore, according to its stock exchange filing.
The company’s consolidated total income also saw a decline, falling to Rs 1,057 crore from Rs 1,127 crore a year earlier — a drop of around 6.2 per cent.
Similarly, revenue from operations decreased by approximately 6.4 per cent, from Rs 1,115.41 crore in the year-ago period to Rs 1,044.54 crore in the last quarter of FY25.
Despite the revenue dip, Jupiter Wagons managed to reduce its total expenses to Rs 923.34 crore in Q4, down 6.4 per cent compared to Rs 986.41 crore in the same quarter last financial year.
However, on a sequential basis, expenses rose by about 1.56 per cent compared to Rs 909.16 crore in Q3.
The company’s EBITDA (earnings before interest, taxes, depreciation, and amortisation) rose slightly to Rs 153 crore from Rs 147 crore last fiscal, with the EBITDA margin improving to 14.6 per cent from 13.2 per cent.
Shares of Jupiter Wagons Limited fell by Rs 13.1 or 3.1 per cent to close the intra-day trading session at Rs 408.95 on the National Stock Exchange (NSE) on Monday.
Speaking about the full financial year, Managing Director Vivek Lohia described FY25 as a transformative year for Jupiter Wagons.
He highlighted several strategic wins, including major contracts with Braithwaite for wheelsets.
“The company also secured brake system contracts worth over Rs 215 crore,” Lohia mentioned.
Lohia emphasised the company’s push into electric mobility with the inauguration of a new facility in Pithampur.
“This state-of-the-art plant is expected to drive battery production and supply to Indian Railways and private partners, along with orders for complete Battery Energy Storage Systems (BESS),” he said.
Tech
How PM Modi-led NDA has curbed retail inflation better than UPA regime

New Delhi, May 14: Official data on Wednesday showed that Prime Minister Narendra Modi-led NDA government had done a much better job in controlling retail inflation — especially in food and fuel — compared to the UPA era.
According to a post by BJP leader Amit Malviya on the X social media platform, “double-digit inflation (over 10 per cent) seen during the UPA era is no longer a concern, reflecting effective governance and price control in the past decade”.
“Since 2014, retail inflation has not crossed 8 per cent, in contrast to the UPA’s 2004–14 average of 8.1 per cent, with 10.4 per cent during 2009–14,” he mentioned, citing the official data.
On the other hand, from January 2012 to April 2014 period during the UPA government, inflation was above 9 per cent in 22 out of 28 months, hitting double digits nine times.
Malviya, the BJP Information Technology cell chief, pointed out that retail inflation in April 2025 fell to 3.16 per cent, the lowest in nearly 6 years, continuing a downward trend.
For FY 2024-25, retail inflation was 4.6 per cent, the lowest since 2018-19, marking three consecutive years of decline.
“Overall, the data indicates better inflation control, especially in food and fuel, under the NDA government compared to the UPA era,” he observed.
The BJP-led NDA government had succeeded in containing inflation with the implementation of concrete steps such as PM Garib Kalyan Anna Yojana which provides more than 80 crore citizens with free rations (extended till 2029), ‘Bharat’ brands launched for retail sale of cereals and pulses at affordable rates through NAFED, NCCF and Kendriya Bhandar.
Besides, under the Price Stabilisation Fund, a dynamic buffer stock of pulses is maintained and calibrated release of stocks from the buffer is done to ensure the availability and affordability of pulses to consumers.
The government is continuously offloading the wheat and rice from the central pool under Open Market Sale Scheme to augment availability in the market and control retail prices.
As far as fuels are concerned, the LPG subsidy and the price of cylinders has been reduced to benefit both PM Ujjwala and regular consumers, prices of non-subsidised LPG were reduced by Rs 100 per 14.2 kg cylinder, effective March 9, 2024.
Business
Chinese missile maker’s stock tanks over 6 pc after India destroys its air weapon

New Delhi, May 13: The shares of Zhuzhou Hongda Electronics Corp Ltd, the Chinese defence company that manufactures the PL-15 missile, dropped sharply by 6.42 per cent or 2.56 Yuan to 37.33 Yuan on Tuesday, after India’s air defence system successfully intercepted and destroyed the missile during the conflict with Pakistan.
Over the past month, the company’s shares have declined by 7.37 per cent, or 2.97 Yuan. However, the stock showed a brief 5-day recovery of 7.58 per cent.
The stock plunge came after Indian defence forces confirmed that the PL-15 missile, supplied to Pakistan by China, failed to penetrate the country’s multi-layered air defence system.
On the night of May 9 and 10, Pakistan launched a series of air attacks targeting Indian Air Force bases and military facilities using advanced weaponry, including the Chinese PL-15 missile and Turkish-made Byker YIHA III kamikaze drones.
However, India’s air defence successfully intercepted all threats.
The PL-15, a beyond-visual-range (BVR) air-to-air missile used by Pakistan’s JF-17 and J-10 fighter jets, was neutralised by indigenous defence systems.
This interception has raised questions about the real-world effectiveness of China’s missile technology, possibly triggering the decline in investor confidence in Zhuzhou Hongda.
India’s Director General of Air Operations, Air Marshal A.K. Bharti, displayed images of the intercepted weapons, showcasing how the Indian defence network had destroyed high-tech missiles and drones.
He credited India’s self-reliant defence capabilities, particularly the indigenous ‘Akash’ air defense system, as a crucial factor in neutralising the threat.
The Akash system, alongside vintage systems like Pichora and advanced platforms including MANPADS, short-range missiles, and fighter aircraft, formed a coordinated defense shield under the Integrated Air Command and Control System.
The Turkish Byker YIHA III drone, capable of carrying high-explosive payloads and designed for low-altitude, high-speed attacks, was also intercepted near Amritsar.
This drone was intended to cause significant damage to military or civilian targets, but failed to breach India’s defenses.
Lieutenant General Rajiv Ghai, Director General of Military Operations (DGMO), explained the multi-layered coordination among the Indian Army, Air Force, and Navy, describing a defence posture that was both measured and impenetrable.
Between May 9 and 10, India’s multi-layered air defence grid was put to the test as waves of drones, launched by the Pakistan Air Force (PAF), attempted to penetrate Indian airspace. “Not a single PAF drone could breach the defence shield,” Lt Gen Ghai stated.
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